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Studies of the inactivation of poliomyelitis yirus by formaldehyde

Inactivation of partially purified virus material and the effect upon the rate of inactivation by addition of glycine

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Summary

The effect upon the rate of formalin-inactivation of poliovirus of formol-binding non-viral material in the medium was studied. It was found that purified virus of types 1 and 3 were inactivated at the same rate as the corresponding crude material. The purified type 2 virus, however, appeared to be more sensitive than the untreated virus. No definite conclusions should be drawn until this has been confirmed in further studies.

Addition of glycine to the medium had a clear-cut retarding effect, reaching appreciable magnitude at molarities of 0.2 or higher.

In confirmation of earlier findings the course of inactivation seemed to followGard'a empirical formula. Calculation of the parameters of the equation and a discussion of their singnificance was attempted.

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Authors and Affiliations

  1. State Bacteriological Laboratory and the Department of Virus Research, School of Medicine, Karolinska Institutet, Stockholm, Sweden

    Erik Lycke

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  1. Erik Lycke
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Lycke, E. Studies of the inactivation of poliomyelitis yirus by formaldehyde. Archiv f Virusforschung 8, 23–41 (1958). https://doi.org/10.1007/BF01242310

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  • DOI: https://doi.org/10.1007/BF01242310

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