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Genetic control of resistance to mouse cytomegalovirus infection

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Summary

A mouse cytomegalovirus (MCMV) recovered from wild (W) mice proved non-infectious for albino Swiss (S) mice and it could not be propagated in cell cultures derived from S embryos. The analysis of the transmission of this feature suggested that the resistance of S mice to that particular MCMV was under genetic control, and this genetic resistance was a unifactorial characteristic Mendelian in nature, being inherited as an autosomal recessive trait. The renal epithelial cells of the host constituted the phenotypic expression of this genetic variation.

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Diosi, P., Arcan, P. & Plavoşif, L. Genetic control of resistance to mouse cytomegalovirus infection. Archiv f Virusforschung 44, 23–27 (1974). https://doi.org/10.1007/BF01242177

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  • DOI: https://doi.org/10.1007/BF01242177

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