Conclusion
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1.
The measles virus can be isolated and fixed to mouse after 5 to 8 serial passages on to the chorio-allantoic membrane of developing chick embryo. Such results were obtained with one strain in 1955, and with five strains in 1957. No virus was isolated by intracerebral inoculation with control saline-passaged chick embryo material to mice of the same litter as used for inoculation of the patient's serum passaged material.
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2.
The newly isolated strains showed common antigenicity with Ohki strain isolated and identified in 1951 by virus neutralization and complement fixation tests.
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3.
Sera taken from patients with the lapse of days, showed the rise and fall of neutralizing and complement fixing antibodies against the mouseadapted measles virus.
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This study was aided in part by grant from the Ministry of Education in 1956 and from Japan Waksman Foundation in 1958.
The authors wish to acknowledge Professor HidetakeYaoi, Director of Department of Bacteriology, Yokohama University School of Medicine, for his kind advices and Professor TomoichiroAkiba, Director of Department of Bacteriology, Medical Faculty of the University of Tokyo for his encouragement.
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Arakawa, S., Hoshino, J., Nagashima, H. et al. Experimental study on measles virus. Archiv f Virusforschung 9, 647–655 (1960). https://doi.org/10.1007/BF01242150
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DOI: https://doi.org/10.1007/BF01242150