Skip to main content
SpringerLink
Log in

A comparative study on muscular involvement in experimental poliomyelitis induced by various strains of virus, and the effect of hyaluronidase on the intramuscular inoculation

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

In Cynomolgus monkeys poliomyelitis-like lesions in the spinal cord, myocarditis and myositis were regularly produced by intramuscular inoculation of viruses of the Columbia SK-MM-EMC group. Various rodent-nonpathogenic strains of human poliomyelitis virus, following intra-muscular inoculation, proved also capable to produce heart and skeletal muscle lesions, which were, however, discrete and transient if paralysis did not develop. The development of paralysis following intramuscular inoculation of human poliomyelitis virus was greatly facilitated by inoculating the virus together with hyaluronidase. The lesions in the skeletal muscles appeared early in the preparalytic stage, and were still demonstrable in the paralytic stage. Columbia SK virus could be recovered from the infected muscle and the blood of inoculated monkeys for at least 4 days following intramuscular inoculation. Human poliomyelitis virus, however, could not be shown in the blood, the heart and skeletal muscle.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jungeblut, C. W.: Proc. Soc. exper. Biol. a. Med. (Am.)72, 534 (1949).

    Article  CAS  Google Scholar 

  2. Jungeblut, C. W.: Bull. N. Y. Acad. Med.26, 571 (1950).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Jungeblut, C. W. andM. A. Stevens: Amer. J. clin. Path.20, 701 (1950).

    Article  CAS  Google Scholar 

  4. Koch, F.: Z. Kinderhk.68, 328 (1950).

    Article  CAS  Google Scholar 

  5. Mollaret, P.: «Le démembrement de la poliomyélite». Paris: Masson. 1950.

    Google Scholar 

  6. Rustigian, R. andA. M. Pappenheimer: J. exper. Med.89, 69 (1949).

    Article  CAS  Google Scholar 

  7. Spain, D. M., V. A. Bradess, andV. Parsonnet: Amer. Heart J.40, 336 (1950).

    Article  CAS  PubMed  Google Scholar 

  8. Verlinde, J. D., P. de Baan, andJ. A. Vercruysse: Antonie van Leeuwenhoek. J. Microbiol. a. Serol.16, 9 (1950).

    CAS  Google Scholar 

  9. Verlinde, J. D., P. de Baan, andP. Waller-Fetter: Antonie van Leeuwenhoek. J. Microbiol. a. Serol.17, 129 (1951).

    CAS  Google Scholar 

  10. Verlinde, J. D. enE. Nihoul: Ndld. Tschr. Geneesk.94, 1186 (1950).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of bacteriology and experimental pathology of the Institute for Preventive Medicine, Leiden, Holland

    J. D. Verlinde

Authors
  1. J. D. Verlinde
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Aided by a grant from the Dr.Simon Baruch Foundation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Verlinde, J.D. A comparative study on muscular involvement in experimental poliomyelitis induced by various strains of virus, and the effect of hyaluronidase on the intramuscular inoculation. Archiv f Virusforschung 4, 546–560 (1952). https://doi.org/10.1007/BF01242022

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01242022

Keywords

Search

Navigation