Summary
In Newcastle disease virus-infected cells the accumulation of virus-specific RNA is prevented if protein synthesis is inhibited by cycloheximide at an early stage of infection. At a later stage cycloheximide enhances the synthesis of smaller (18–35 S) virus-specific RNA while the synthesis of 49 S RNA is suppressed. This is accompanied by a corresponding change in the relative amounts of “plus” and “minus” RNA strands: the proportion of “plus” strand is sharply decreased. A possible significance of the phenomenon for the regulation of virus-specific RNA synthesis is discussed.
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Kaverin, N.V., Varich, X.L. Virus-specific RNA formed in Newcastle disease virus-infected cells after suppression of protein synthesis by cycloheximide. Archiv f Virusforschung 35, 378–384 (1971). https://doi.org/10.1007/BF01241918
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DOI: https://doi.org/10.1007/BF01241918