Summary
The properties of non-specific vaccinia-haemagglutination inhibitors are compared with those of specific haemagglutination-inhibiting antibodies. Non-specific inhibitors are contained in various human body fluids, viz. in cerebrospinal fluids with pathologically high protein contents, further in pleural, peritoneal and synovial fluids as also in the hydrocele of testis and sometimes in fluids drawn from ovarian cysts. As regards prompt onset of the reaction with haemagglutinins at different temperatures, there seems to be no difference between non-specific inhibitiors and specific HAI antibodies. Also non-specific inhibitors combine proportionately with haemagglutinins and are not adsorbed to the erythrocytes. They are less heat-resistant than, but require the same temperature for complete destruction as, specific inhibitors. Digestion by trypsin and adsorption to kaolin do not affect specific HAI antibodies, while non-specific inhibitors can in most cases be removed from the body fluids by these treatments.
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Szathmáry, J. Studies on the non-specific inhibition by some body fluids against vaccinia haemagglutination. Archiv f Virusforschung 10, 540–549 (1961). https://doi.org/10.1007/BF01241890
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DOI: https://doi.org/10.1007/BF01241890