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Stability of visna virus in infectious tissue culture fluid

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Summary

The effect of various physical and chemical agents on the stability of TC visna virus was studied. It was found, that storage at −50° C for several months and repeated freezing and thawing did not cause a significant loss of titer. At temperatures from 0° to 47° C the infectivity was gradually lost, the 90 per cent inactivation period being from 30 days to 27 minutes. Heating at 57° C for 28 minutes inactivated the virus completely. The virus was found to be most stable at slightly alkaline pH. It was easily inactivated by formaldehyde, ethyl alcohol and phenol. Ethyl ether and trypsin were also found to cause inactivation of visna virus.

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References

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Authors and Affiliations

  1. Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavík

    Halldór Thormar

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  1. Halldór Thormar
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This work was supported by the Icelandic Science Foundation.

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Thormar, H. Stability of visna virus in infectious tissue culture fluid. Archiv f Virusforschung 10, 501–509 (1961). https://doi.org/10.1007/BF01241886

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  • DOI: https://doi.org/10.1007/BF01241886

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