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Homotypic and heterotypic antibody response in infants to adenovirus vaccine

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Summary

Two or three doses of inactivated monkey kidney tissue culture propagated adenovirus vaccine containing types 3, 4 and 7, or three doses of placebo fluid were administered to 271 infants 3 to 12 months of age. Vaccination was not associated with any clinical reactions.

The first dose of vaccine produced a poor response, whereas the second and third doses stimulated high levels of neutralizing antibody to types 3, 4 and 7. The response in infants without pre-existing antibody did not deviate significantly from that in initially antibody-positive infants. Three doses of vaccine were found to produce neutralizing antibody in 97—100% of the infants. Antibody persisted for at least one year in 70—100% of 35 infants studied, although the titers decreased substantially. Low levels of heterotypic antibody to types 14 and 21 developed in, respectively, 76% and 18% of initially antibody-negative infants after two or three doses of vaccine.

The neutralizing antibody response observed 6 months after administration of one dose of vaccine was substantially higher than that found one month after the first injection.

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Authors and Affiliations

  1. Laboratory of Bacteriology and Virology, St. Elisabeth Hospital, Tilbuxg, The Netherlands

    J. van der Veen, D. J. van Zaane, M. A. J. Sprangers & C. F. A. Heyen

  2. Department of Pediatrics, St. Elisabeth Hospital, Tilburg, The Netherlands

    J. van der Veen, D. J. van Zaane, M. A. J. Sprangers & C. F. A. Heyen

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  1. J. van der Veen
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  2. D. J. van Zaane
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  3. M. A. J. Sprangers
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  4. C. F. A. Heyen
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van der Veen, J., van Zaane, D.J., Sprangers, M.A.J. et al. Homotypic and heterotypic antibody response in infants to adenovirus vaccine. Archiv f Virusforschung 21, 320–333 (1967). https://doi.org/10.1007/BF01241733

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  • DOI: https://doi.org/10.1007/BF01241733

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