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Antibody levels in human sera to oncogenic adenoviruses (types 7, 12 and 18)

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Summary

Neutralizing antibodies for adenovirus types 7, 12 and 18 were compared for a collection of human serum. In specimens from adults antibody for adenovirus types 12 and 18 were less common than for adenovirus type 7. However, antibody for type 7 appeared to develop later in childhood than for types 12 and 18. In sera with detectable antibody the neutralization titres for adenovirus types 12 and 18 were lower than for type 7.

Quantitatively, the neutralization reactions for adenovirus types 7, 12 and 18 were similar but differed from that observed with adenovirus types 1 and 5. The results were taken to indicate that the low titre of antibody for adenovirus types 12 and 18 in human sera could not be explained on the basis of quantitative differences in the neutralization reaction but suggest that these strains are only weakly antigenic in man.

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Authors and Affiliations

  1. The Department of Bacteriology, University of Sheffield, UK

    C. W. Potter & G. C. Schild

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  1. C. W. Potter
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  2. G. C. Schild
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Potter, C.W., Schild, G.C. Antibody levels in human sera to oncogenic adenoviruses (types 7, 12 and 18). Archiv f Virusforschung 18, 80–87 (1966). https://doi.org/10.1007/BF01241703

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  • DOI: https://doi.org/10.1007/BF01241703

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