Summary
Frater virus, a cytopathogenic agent isolated from cases of aseptic meningitis in Scotland in 1959, was found to resemble the ECHO viruses in its properties. It was not pathogenic for laboratory animals or for hens' eggs, but produced cytopathic changes in cultures of human and monkey tissues. Human thyroid was more susceptible to infection than human amnion, and amnion more than monkey kidney, while HeLa cell cultures failed to show any cytopathic effects. Serologically no relationship was detected between Prater virus and polioviruses, Coxsackie viruses, ECHO virus types 1 to 27, herpes simplex virus and adenoviruses. Among different strains of Frater virus some antigenic variation was detected. Frater virus is thought to be a new type of ECHO virus.
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Duncan, I.B.R. Biological and serological properties of Frater virus — a cytopathogenic agent associated with aseptic meningitis. Archiv f Virusforschung 11, 248–257 (1961). https://doi.org/10.1007/BF01241689
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DOI: https://doi.org/10.1007/BF01241689