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Susceptibility of human tumor cells to ECHO viruses and loss of hemagglutinating capacity of some of the adapted viruses

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Summary

Prototype ECHO viruses were studied quantitatively for their ability to adapt to stationary tube cultures of HeLa and KB human tumor cell lines, and for the hemagglutinating activity of the human tumor cell (HTCC) adapted ECHO viruses.

According to criteria presented, ECHO types 2, 3, 6, 9, 11, 19, 20, and 24 adapted to HeLa cells, and these plus type 5, were propagated in KB cultures.

However other lines of HeLa and KB cells that we obtained subsequently did not exhibit the same susceptibility to these ECHO viruses. HTCC adapted types 3, 11, and 19 lost their hemagglutinating capacity, which was not regained by passage back in monkey kidney cell cultures.

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Authors and Affiliations

  1. Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado

    John Maisel M. D. (Fellow of The National Foundation), Carlo Moscovici Ph. D. & Michele La Placa M. D. (Fellow of the Italian Research Council)

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  1. John Maisel M. D.
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  2. Carlo Moscovici Ph. D.
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  3. Michele La Placa M. D.
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Supported by a grant from The National Foundation.

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Maisel, J., Moscovici, C. & La Placa, M. Susceptibility of human tumor cells to ECHO viruses and loss of hemagglutinating capacity of some of the adapted viruses. Archiv f Virusforschung 11, 209–214 (1961). https://doi.org/10.1007/BF01241686

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  • DOI: https://doi.org/10.1007/BF01241686

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