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Blocking of interferon action by a component of normal serum

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Summary

Normal fetal calf serum and sera from a variety of other animal species have been found to suppress the antiviral action of interferon in chick embryo cells. The amount of suppression of interferon action was dependent on the concentration of the serum and the concentration of interferon; the effect increased with the concentration of serum and decreased with the concentration of interferon. The active component is of macromolecular nature, it is trypsin-resistant and inactivated by extraction with organic solvents. It is found mainly in Color's Fractions III and IV. Certain properties of the active component in fetal calf serum suggested that it may be associated with a lipoprotein.

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Author notes

  1. T. G. Rossman

    Present address: Department of Pathology, New York University Medical Center, 10016, New York, NY, USA

Authors and Affiliations

  1. Department of Microbiology, New York University Medical Center, New York, USA

    T. G. Rossman & J. Vilček

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  1. T. G. Rossman
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  2. J. Vilček
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Additional information

Dedicated to Professor Dr. Dr. C.Hallauer on the occasion of his 70th birthday.

This work was taken in part from a dissertation by T. G. Rossman submitted to the faculty of New York University in partial fulfillment of the requirements for the Ph. D. degree.

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Rossman, T.G., Vilček, J. Blocking of interferon action by a component of normal serum. Archiv f Virusforschung 31, 18–27 (1970). https://doi.org/10.1007/BF01241662

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  • DOI: https://doi.org/10.1007/BF01241662

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