Skip to main content

Advertisement

SpringerLink
Log in

Platelet aggregation by herpes simplex antigen-antibody complexes

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

The platelet aggregation test, a recently developed serological method for measuring antibodies against small size (soluble) viral antigens, was used to study herpes simplex virus infections. Sera of 100 healthy persons and paired sera from 25 hospitalized patients suffering from acute HSV infection were tested by CF and PA techniques. In the serological survey the results of CF and PA were in 98% accordance. About half (13/25) of the acute HSV infections remained negative in the PA test despite definite rises in CF antibodies. Seroconversion in PA was observed only in 4 cases. The different behaviour of PA antibodies in recurrent and acute HSV infection is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hayward, M. E.: Serological diagnosis of herpes simplex virus infections. LancetI, 856–858 (1950).

    Google Scholar 

  2. Hopps, H. E., B. C. Bernheim, A. Nisalak, J. H. Tjio, andJ. E. Smadel: Biological characteristics of a continuous kidney cell line derived from the African green monkey. J. Immunol.91, 416–424 (1963).

    Google Scholar 

  3. Lennette, E. H.: In: Diagnostic Procedures for Viral and Rickettsial Diseases, p. 57. E. H. Lennette and N. J. Schmidt, Eds., New York: American Public Health Association, 1964.

    Google Scholar 

  4. Mylltlä, G., A. Vaheri, T. Vesikari, andK. Penttinen: Interaction between human blood platelets, viruses and antibodies. IV. Postrubella thrombocytopenic purpura and platelet aggregation by rubella antigen-antibody interaction. Clin, exp. Immunol.4, 323–333 (1969).

    Google Scholar 

  5. Mäntyjärvi, R.: Precipitating antibody response to herpes simplex virus in rabbits after herpetic keratoconjunctivitis. Acta path, microbiol. scand.65, 581–586 (1965).

    Google Scholar 

  6. Penttinen, K., andG. Myllylä: Interaction in human blood platelets, viruses and antibodies. I. Platelet aggregation test with microequipment. Ann. Med. exp. Fenn.46, 188–192 (1968).

    Google Scholar 

  7. Penttinen, K., G. Myllylä, O. Mäkelä, andA. Vaheri: Soluble antigenantibody complexes and platelet aggregation. Acta path. microbiol. scand.77, 309–317 (1969).

    Google Scholar 

  8. Penttinen, K., P.Saikku, G.Myllylä, M.Brummer-Korvenkontio, and N.Oker-Blom: The platelet aggregation test in group B arbovirus infections. J. Hyg., in press (1970).

  9. Penttinen, K., L. Kääriäinen, andG. Myllylä: Cytomegalovirus antibody assay by platelet aggregation. Arch. ges. Virusforsch.29, 189–194 (1970).

    Google Scholar 

  10. Ross, C. A. C., W. C. Russel, andP. Wildt: Herpes antigens from hamster kidney cell cultures in the diagnosis of primary and recurrent infections. Arch. ges. Virusforsch.15, 58–66 (1964).

    Google Scholar 

  11. Tokumaru, T.: Studies of herpes simplex virus by the gel diffusion technique. I. Distribution of precipitating antibodies among human sera. J. Immunol.95, 181–188 (1965).

    Google Scholar 

  12. Tokumaru, T., andT. F. McN. Scott: In: Diagnostic Procedures for Viral and Rickettsial Diseases, p. 402–406.E. H. Lennette andN. J. Schmidt, Eds., New York: American Public Health Association, 1964.

    Google Scholar 

Download references

Author information

Author notes

  1. T. Palosuo

    Present address: Department of Virology, University of Helsinki, Finland

Authors and Affiliations

  1. Department of Virology, University of Helsinki, Finland

    K. Penttinen & G. Myllylä

  2. The Finnish Red Cross Blood Transfusion Service, Helsinki, Finland

    T. Palosuo, K. Penttinen & G. Myllylä

Authors
  1. T. Palosuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Penttinen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Myllylä
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to Professor Dr. Dr. C.Hallauer on the occassion of his 70th birthday.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Palosuo, T., Penttinen, K. & Myllylä, G. Platelet aggregation by herpes simplex antigen-antibody complexes. Archiv f Virusforschung 31, 11–17 (1970). https://doi.org/10.1007/BF01241661

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01241661

Keywords

Search

Navigation