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Cytomegalovirus infections in organ transplantation and post transfusion

An Hypothesis

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Summary

The incidence and manifestations of cytomegalovirus (CMV) infections after organ transplantation and transfusion is reviewed. Since transfused individuals receive unmatched leukocytes, they share certain responses with recipients of organ grafts. In this regard enhanced replication of lymphoid elements, probably common to both groups, may be responsible for the frequent occurrence of primary as well as reactivated CMV infections in these patients. New CMV infections may be transmitted within transplanted cells — in blood leukocytes, wandering macrophages, infected and sloughed endothelial cells, or in carrier cells latently infected within an organ. Reticuloendothelial cells of the donor and the recipient receive a significant antigenic stimulus after transplantation or perfusion. This may lead to the replication and release of latent CMV if the virus is endogenous to the recipient or if it has been transmitted with leukocytes or within a donated organ. The nature of the resultant clinical illness depends in part upon the prior CMV antibody status of the recipient. Immunosuppressive regimens administered to organ recipients probably enhance the dissemination of CMV but not the acquisition of the virus.

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  1. David J. Lang

    Present address: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

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    This paper was supported in part by a grant from the National Institutes of Health # 7 RO1 HDO4183-01 and by a grant from the American Cancer Society #IN-61J-5.

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    Lang, D.J. Cytomegalovirus infections in organ transplantation and post transfusion. Archiv f Virusforschung 37, 365–377 (1972). https://doi.org/10.1007/BF01241460

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