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Ultrastructural characterization of a new member of the Rhabdovirus group-Klamath virus

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Summary

Klamath virus was observed by negative contrast and thin section electron microscopy. Bullet-shaped particles in infected cell cultures had mean dimensions of 167×80 nm and were typical of members of the Rhabdovirus group. In infected mouse brain, virus particles budded from intracytoplasmic membranes in association with a prominent matrix. Although the virus is serologically unrelated to any of the known Rhabdoviruses of animals, this intracytoplasmic accumulation of virus particles and matrix with little frank cytopathology, most closely resemblesin vivo rabies virus infection.

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Author notes

  1. Frederick A. Murphy

    Present address: Center for Disease Control, Health Services and Mental Health Administration Public Health Service, U.S. Department of Health, Education, and Welfare, 30333, Atlanta, Georgia, USA

Authors and Affiliations

  1. Center for Disease Control, Health Services and Mental Health Administration Public Health Service, U.S. Department of Health, Education, and Welfare, 30333, Atlanta, Georgia, USA

    Alyne K. Hareison

  2. California State Department of Public Health, Berkeley, California, USA

    Harald N. Johnson

  3. Yale Arbovirus Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA

    Robert E. Shope

Authors
  1. Frederick A. Murphy
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  2. Harald N. Johnson
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  3. Alyne K. Hareison
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  4. Robert E. Shope
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Murphy, F.A., Johnson, H.N., Hareison, A.K. et al. Ultrastructural characterization of a new member of the Rhabdovirus group-Klamath virus. Archiv f Virusforschung 37, 323–331 (1972). https://doi.org/10.1007/BF01241455

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  • DOI: https://doi.org/10.1007/BF01241455

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