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Mouse hepatitis virus and interferon production in normal and regenerating liver

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Summary

The multiplication of two strains of mouse hepatitis virus, a virulent (MHV-3) and a mild (MHV-1) strain, and the course of interferon production were followed in normal mice and in mice with livers regenerating after partial hepatectomy. Virus growth in regenerating tissue was faster and attaining higher levels than in normal livers. The yield of interferon also increased during regeneration, and recovery from the infection produced by MHV-1 may be related to the ratio between interferon and virus yield.

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Authors and Affiliations

  1. The Division of Bacteriology and Virus Research National Institute forMedical Research, Mill Hill, London, N. W. 7

    Livio Mallucci

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  1. Livio Mallucci
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Additional information

This study was undertaken during tenure of a N.A.T.O. Fellowship granted by the Italian National Research Council.

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Mallucci, L. Mouse hepatitis virus and interferon production in normal and regenerating liver. Archiv f Virusforschung 15, 91–97 (1964). https://doi.org/10.1007/BF01241424

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  • DOI: https://doi.org/10.1007/BF01241424

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