Summary
18 of 39 adenovirus strains of group II were found to be serologically intermediate: they were related to one serotype in hemagglutinationinhibition and to another in neutralization. They have been designated with two type numbers, the first indicating the type related in HA-inhibition, the second that related in neutralization. The strains were classified into ten different serological categories. Three or possibly two more of the “type halves” were hitherto unknown new antigens. A further strain was found to have antigenic constituents of both types 26 and 27, demonstrable in both serological tests.
Six of the prototypes of group II were also classified by two type numbers, indicating the close relationship between the respective types: 8 and 9, 10 and 19, 15 and 22 in hemagglutination-inhibition, 15 and 25, 15 and 29, 13 and 30 in neutralization.
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Bauer, H., R. Wigand undW. Adam: Lösliche und virusgebundene Adenovirus-Hämagglutinine. Z. Naturforsch.19b, 587–593 (1964).
Bauer, W., undR. Wigand: Vergleichende Untersuchungen an Hämagglutininen von Adenovirusstämmen der Gruppen I und II. Arch. ges. Virusforsch.21, 11–24 (1967).
Bell, S. D. Jr.,T. R. Rota, andD. E. McComb: Adenoviruses isolated from Saudi Arabia. III. Six new serotypes. Amer. J. trop. Med. Hyg.9, 523–526 (1960).
Brandt, C. F., F. E. Wassermann, andJ. P. Fox: The virus watch program. IV. Recovery and comparison of two serological varieties of adenovirus type 5. Proc. Soc. exp. Biol. (N.T.)123, 513–518 (1966).
Cramblett, H. G., J. A. Kasel, M. Langmack, andF. D. Wilken: Illnesses in children infected with an adenovirus antigenically related to types 9 and 15. Pediatrics25, 822–828 (1960).
Gelderblom, H., W. Meiser, A. Lengyel, andR. Wigand: The serological relationship of the soluble antigens of adenovirus type 19. J. gen. Virol.2, 331–340 (1968).
Hatch, M. H., andR. M. Siem: Viruses isolated from children with infectious hepatitis. Amer. J. Epidem.84, 495–509 (1966).
Jung, D., andR. Wigand: Epidemiology of group II adenoviruses. Amer. J. Epidem.85, 311–319 (1967).
Matumoto, M., S. Uchida, T. Hoshika, andT. Matsuyama: Isolation of an intermediate type of adenovirus from a fatal case of infantile pneumonia. Jap. J. exp. Med.28, 305–315 (1958).
Parks, W. P., L. M. Queiroga, J. L. Melnick, andH. G. Pereira: Recent adenovirus isolates exhibiting broad intratypic and intertypic antigenicity. Proc. Soc. exp. Biol. (N.T.)125, 498–503 (1967).
Rosen, L.: A hemagglutination-inhibition technique for typing of adenoviruses. Amer. J. Hyg.71, 120–128 (1960).
Rosen, L., S. Baron, andJ. A. Bell: Four newly recognized adenoviruses. Proc. Soc. exp. Biol. (N.T.)107, 434–437 (1961).
Rosen, L., J. F. Hovis, andJ. A. Bell: Further observation on typing adeno-viruses and a description of two possible additional serotypes. Proc. Soc. exp. Biol. (N.Y.)110, 710–713 (1962).
Rowe, W. P., J. W. Hartley, andR. J. Huebner: Serotype composition of the adenovirus group. Proc. Soc. exp. Biol. (N.T.)97, 465–470 (1958).
Wigand, R.: Serologisch intermediäre Adenovirusstämme. Arch. ges. Virusforsch.17, 611–618 (1965).
Wigand, R.: Serologische Beziehungen der Adenoviren der Gruppe II. Arch. ges. Virusforsch.23, 40–47 (1968).
Wigand, R., undH. Bauer: Über den cytopathogenen Effekt der Adenoviren des Menschen. Arch. ges. Virusforsch.14, 674–682 (1964).
Wigand, R., H. Bauer, F. Lang, andW. Adam: Neutralization of the adenoviruses types 1 to 28: specificity and antigenic relationships. Arch. ges. Virusforsch.15, 188–199 (1965).
Wigand, R., andW. Wunn: Virus-associated and soluble adenovirus hemagglutinins: differences in antigenic specificity. Virology28, 484–485 (1966).
Wilcox, W. C., andH. S. Ginsberg: Production of specific neutralizing antibody with soluble antigens of type 5 adenovirus. Proc. Soc. exp. Biol. (N.T.)114, 37–42 (1963).
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Wigand, R., Fliedner, D. Serologically intermediate adenovirus strains: A Regular feature of group II adenoviruses. Archiv f Virusforschung 24, 245–256 (1968). https://doi.org/10.1007/BF01241296
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DOI: https://doi.org/10.1007/BF01241296