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Determination of different cytomegalovirus immunoglobulins (IgG, IgA, IgM) by immunofluorescence

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Summary

Cytomegalovirus (CMV) immunoglobulins were determined by immunofluorescence. CMV IgM-antibodies usually reach relatively high titers soon after infection and can be detected in the blood of patients 2–8 months post infection. This confirms the experience that demonstration of CMV-IgM-antibodies is a suitable indicator of recent infection. CMV-IgM-antibodies were found in cases of clinical infectious mononucleosis.

The development of CMV antibodies types IgM and IgA was followed up in some patients over a period of several months. IgA-antibodies do not react with complement and therefore cannot be detected by complement-fixation-test (CFT). The immunofluorescence techniques proved as a useful means for the detection of CMV-IgA-antibodies. Immunofluorescence techniques are more suitable for CMV-antibody determinations than CFT.

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  1. H. Schmitz

    Present address: Hygieneinstitut der Universität Freiburg, Freiburg (Breisgau), BRD

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  1. Hygieneinstitut der Universität Freiburg, Freiburg (Breisgau), BRD

    R. Haas

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  1. H. Schmitz
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Schmitz, H., Haas, R. Determination of different cytomegalovirus immunoglobulins (IgG, IgA, IgM) by immunofluorescence. Archiv f Virusforschung 37, 131–140 (1972). https://doi.org/10.1007/BF01241158

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  • DOI: https://doi.org/10.1007/BF01241158

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