Summary
Sendai virus inoculated into the heart of guinea-pigs was demonstrated to produce interferon, which reached a peak at 5 hours. Protection was afforded against foot-and-mouth disease virus from 24 hours before to 24 hours after challenge. No inhibition of interferon or antibody production was demonstrated when Sendai virus was administered at the same time as inactivated foot-and-mouth disease vaccine and no significant effect on the 50% protection dose of vaccine was found. Guinea-pigs given Sendai virus and inactivated vaccines simultaneously were protected from development of foot-and-mouth disease secondary lesions from 5 hours after the time of inoculation, although interferon and antibody were not detected on the second and third days.
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Herniman, K.A.J., Sellers, R.F. Protection of guinea-pigs against foot-and-mouth disease by simultaneous inoculation of sendai virus and inactivated foot-and-mouth disease vaccine. Archiv f Virusforschung 37, 97–103 (1972). https://doi.org/10.1007/BF01241155
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DOI: https://doi.org/10.1007/BF01241155