Summary
Aedes aegypti mosquito cell cultures inoculated with eastern equine encephalitis (EEE) virus, yielded at the height of infection about 50% virus-producing cells, and a calculated amount of 600 PFU per infected cell, yet CPE was not observed. Cultures co-infected with EEE and Semliki Forest (SF) viruses supported the proliferation of both viruses, but no CPE or other evidence for the enhancement of infection was manifested. The apparent absence of doubly infected cells in cultures exposed simultaneously to EEE and SF viruses suggested that the two viruses were proliferating in different target cells.
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This investigation was supported by Research Grant 06-325-01 from the US Public Health Service, Bureau of State Services.
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Peleg, J. Studies on the behavior of arboviruses in an Aedes aegypti mosquito cell line (Peleg). Archiv f Virusforschung 37, 54–61 (1972). https://doi.org/10.1007/BF01241150
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DOI: https://doi.org/10.1007/BF01241150