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Study of interferonogenic activity of herpes simplex virus

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Summary

The interferon-inducing activity of herpes simplex virus strains, belonging to different antigenic groups was studied in chick fibroblast cultures. Only the initial variant of strain K and its plaque-forming clones were found to possess the ability to induce interferon. The optimal conditions for interferon formation were studied and the intensity of interferon synthesis was shown to be directly proportional to the multiplicity of infection. Clarification of “opaque” plaques formed by clones of strain K in the presence of 5-bromodeoxyuridine and during incubation of the infected cell culture at 28° C strongly suggested the correlation between interferon production and the ability of the clones of strain K to form opaque plaques.

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References

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Author notes

  1. I. A. Rudneva

    Present address: D.I. Ivanovsky Institute of Virology, The USSR Academy of Medical Sciences, Moscow, USSR

Authors and Affiliations

  1. D.I. Ivanovsky Institute of Virology, The USSR Academy of Medical Sciences, Moscow, USSR

    N. I. Korabelnikova, A. B. Germanov, M. I. Sokolov & L. L. Fadeeva

Authors
  1. I. A. Rudneva
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  2. N. I. Korabelnikova
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  3. A. B. Germanov
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  4. M. I. Sokolov
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  5. L. L. Fadeeva
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Rudneva, I.A., Korabelnikova, N.I., Germanov, A.B. et al. Study of interferonogenic activity of herpes simplex virus. Archiv f Virusforschung 37, 1–5 (1972). https://doi.org/10.1007/BF01241144

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  • DOI: https://doi.org/10.1007/BF01241144

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