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Connective tissue influences on the expression of epithelial cell-surface antigens

Cell and Tissue Research volume 248, pages 137–141 (1987)Cite this article

Summary

Adult mice were found to show regional variation in the epithelial expression of some molecules of the blood-group antigen series. To investigate connective tissue influences on such differences, heterotypic recombinants of epithelia and connective tissues from various regions were prepared and examined using monoclonal antibodies directed against bloodgroup antigens H and Ley. The results indicate that epithelia may maintain a preexisting regionally specific pattern following recombination but that, in some recombinant matches, the connective tissue is capable of signalling redirection of the pattern of expression towards that typical of the epithelium with which it is normally associated.

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Affiliations

  1. Dows Institute for Dental Research, University of Iowa College of Dentistry, Iowa City, Iowa, USA

    Ian C. Mackenzie

  2. Royal Dental College Copenhagen, Denmark

    Erik Dabelsteen

Authors
  1. Ian C. Mackenzie
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  2. Erik Dabelsteen
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Additional information

This work was supported by NIH-NIDR RO1-DEO-5190

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Mackenzie, I.C., Dabelsteen, E. Connective tissue influences on the expression of epithelial cell-surface antigens. Cell Tissue Res. 248, 137–141 (1987). https://doi.org/10.1007/BF01239974

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  • DOI: https://doi.org/10.1007/BF01239974

Key words

  • Epitheliomesenchymal interactions
  • Blood-group antigens
  • Skin
  • Mucosa
  • Mouse