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Archives of Toxicology

, Volume 54, Issue 3, pp 243–246 | Cite as

Effects of manganese ions on thyroid function in rat

  • Anne -Marie Buthieau
  • Nicole Autissier
Original Investigations

Abstract

Rats were treated with MnSO4, H2O (1 mg/100 g/day, SC) for a period of 5 weeks. Thyroxine (T4) and triiodothyronine (T3) levels were measured in thyroid by radioimmunoassay. T4, T3 and thyroid-stimulating hormone (TSH) levels were also estimated by radioimmunoassay in serum. Manganese treatment produced no change in thyroid T4 and T3 levels but induced a significant decrease in serum T4, T3 and TSH levels. This decrease can be interpreted as the result of a pituitary alteration which appears to be related to the high accumulation of manganese in the pituitary gland.

Key words

Manganese Thyroid hormones Thyroid Serum Rat 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Anne -Marie Buthieau
    • 1
  • Nicole Autissier
    • 1
  1. 1.Chimie Analytique et Bromatologie, UER des Sciences Pharmaceutiques et Biologiques, UER NutritionUniversité de DijonDijonFrance

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