Summary
Systematic sampling of human necropsy pancreases has revealed that pancreatic polypeptide (PP) cells are not distributed equally in the gland. PP-cells are the most abundant cell type in the posterior part of the pancreatic head while they are scarce or absent in the remainder of the gland. The PP-rich part of the head can be separated by blunt dissection from the pancreas as a discrete lobe. This lobe probably originates from the ventral pancreatic bud during embryogenesis. A quantitative study of the immunofluorescent endocrine cell types (insulin, glucagon, somatostatin and pancreatic polypeptide cells) in PP-rich and PP-poor regions of pancreases in 8 subjects with ages ranging from 33 fetal weeks to 80 years, showed that the proportions of the cell types were different in youngs and adults.
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Malaisse-Lagae, F., Stefan, Y., Cox, J. et al. Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide. Diabetologia 17, 361–365 (1979). https://doi.org/10.1007/BF01236270
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DOI: https://doi.org/10.1007/BF01236270