The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

Somatic Cell and Molecular Genetics volume 17, pages609–615(1991)Cite this article

Abstract

The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine homolog ofLHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.

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Literature cited

  1. 1.

    Schally, A.V., Arimura, A., Kastin, A.J., Matsuo, H., Baba, Y., Redding, T.W., Nair, R.M.G., and Debeljuk L. (1971).Science 1731036–1038.

    Google Scholar 

  2. 2.

    Burgus, R., Butcher, M., Amoss, M., Ling, N., Monahan, M., Rivier, J., Fellows, R., Blackwell, R., Vale, W., and Guilleman, R. (1972).Proc. Natl. Acad. Sci. U.S.A. 69278–282.

    Google Scholar 

  3. 3.

    Nikolics, K., Mason, A.J., Szonyi, E., Ramachandran, J., and Seeburg, P.H. (1985).Nature 316511–517.

    Google Scholar 

  4. 4.

    Matsuo, H., Baba, Y., Nair, R.M.G., Arimura, A., and Schally, A.V. (1971).Biochem. Biophys. Res. Commun. 431334–1339.

    Google Scholar 

  5. 5.

    Adelman, J.P., Mason, A.J., Hayflick, J.S., and Seeburg, P.H. (1983).Proc. Natl. Acad. Sci. U.S.A. 83179–183.

    Google Scholar 

  6. 6.

    Mason, A.J., Hayflick, J.S., Zoeller, R.T., Young, W.S., Phillips, H., Nikolics, K., and Seeburg, P.H. (1986).Science 2341366–1371.

    Google Scholar 

  7. 7.

    Yan-Feng, T.L., Seeburg, P.H., and Franke, U. (1986).Somat. Cell. Mol. Gen. 1295–100.

    Google Scholar 

  8. 8.

    Cattanach, B.M., Iddon, C.A., Charlton, H.M., Chiappa, S.A., and Fink, G. (1977).Nature 269338–340.

    Google Scholar 

  9. 9.

    Mason, A.J., Pitts, S.L., Nikolics, K., Szonyi, E., Wilcox, J.N., Seeburg, P.H., and Stewart, T.A. (1986).Science 2341372–1378.

    Google Scholar 

  10. 10.

    Lang, J. (1991).Mouse Genome (in press).

  11. 11.

    Love, J., Knight, A., McAleer, M., and Todd, J. (1990).NAR 184123–4130.

    Google Scholar 

  12. 12.

    Hearne, C.M., McAleer, M.A., Loce, J.M., Aitman, T.J., Cornall, R.J., Ghosh, S., Knight, A., Prins, J.-B., and Todd, J.A. (1991).Mammal. Genome (in press).

  13. 13.

    Hug, H., Costas, M., Staehli, P., Aebi, M., and Weissmann, C. (1988).Mol. Cell Biol. 83065–3079.

    Google Scholar 

  14. 14.

    Lyon, M.F., and Kirby, M. (1991).Mouse Genome 8954.

    Google Scholar 

  15. 15.

    Laval, S.H., and Boyd, Y. (1991).Cytogenet. Cell Genet. (in press).

  16. 16.

    Brown, S.D.M., Avner, P.A., Chapman, V.M., Hamvas, R.M.J., and Herman, G.E. (1991).Mammal. Genome 1S318-S331.

    Google Scholar 

  17. 17.

    Nichols, E.A., and Ruddle, F.H. (1975).Biochem. Genet. 13323–329.

    Google Scholar 

  18. 18.

    Todd, J.A., Aitman, T.J., Cornall, R.J., Ghoso, S., Hall, J.R.S., Hearne, C.M., Knight, A.M., Love, J.M., McAleer, M.A., Prins, J.-B., Rodrigues, N., Lathrop, M., Pressey, A., DeLarato, N.H., Peterson, L.B., and Wicker, L.S. (1991).Nature 351542–547.

    Google Scholar 

  19. 19.

    Hurst, J., Flavell, D., Julien, J.-P., Meijer, D., Mushynski, W., and Grosveld, F. (1987).Cytogenet. Cell Genet. 4530–32.

    Google Scholar 

  20. 20.

    Somerville, M.J., and McLachlan, D.R. (1988).Genome 30499–500.

    Google Scholar 

  21. 21.

    Tsui, L.-C., Farrall, M., and Donis-Keller, H. (1989).Cytogenet. Cell Genet. 51166–201.

    Google Scholar 

  22. 22.

    Ceci, J.D., Justice, M.J., Lock, L.F., Jenkins, N.A., and Copeland, N.G. (1990).Genomics 672–79.

    Google Scholar 

  23. 23.

    Sparkes, R.S., Zollman, S., Klisak, I., Kirchgessner, T.G., Komaromy, M.C., Mohandas, T., Schotz, M.C., and Lusis, A.J. (1987).Genomics 1138–144.

    Google Scholar 

  24. 24.

    Oulette, A.J., Pratchevna, D., Ruddle, F.H., and James, M. (1989).Genomics 5233–239.

    Google Scholar 

  25. 25.

    Doolittle, D.P., Davisson, M.T., Roderick, T.H., and Hillyard, A.L. (1990).Mouse Genome 8720.

    Google Scholar 

  26. 26.

    Lalley, P.A., Davisson, M.T., Graves, J.A.M., O'Brien, S.J., Womack, J.E., Roderick, T.H., Creau-Goldberg, N., Hillyard, A.L., Doolittle, D.P., and Rogers, J.A. (1989).Cytogenet. Cell Genet. 51503–532.

    Google Scholar 

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Affiliations

  1. Genetics Division (Harwell), MRC Radiobiology Unit, OX11 ORD, Chilton, Didcot, Oxon, England

    Penny Williamson & Yvonne Boyd

  2. Department of Human Anatomy, university of Oxford, South Parks Road, OX1 3QX, Oxford, England

    Jill Lang

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  1. Penny Williamson
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  2. Jill Lang
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  3. Yvonne Boyd
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Williamson, P., Lang, J. & Boyd, Y. The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8. Somat Cell Mol Genet 17, 609–615 (1991). https://doi.org/10.1007/BF01233626

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Keywords

  • Somatic Cell
  • Human Chromosome
  • Cell Hybrid
  • Homologous Region
  • Mouse Chromosome