The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

Abstract

The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine homolog ofLHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.

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Williamson, P., Lang, J. & Boyd, Y. The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8. Somat Cell Mol Genet 17, 609–615 (1991). https://doi.org/10.1007/BF01233626

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Keywords

  • Somatic Cell
  • Human Chromosome
  • Cell Hybrid
  • Homologous Region
  • Mouse Chromosome