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Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport, and superoxide generation, to human chromosome region 16q22

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Somatic Cell and Molecular Genetics

Abstract

De novo UMP synthesis is a critical metabolic pathway for nucleic acid synthesis and for a variety of metabolic pathways. The pathway is a target for many widely used cancer chemotherapy agents, several of which are pyrimidine analogs. Humans and cattle have been described with mutations in UMP synthesis that lead to serious inborn errors of metabolism. Dihydroorotate dehydrogenase (EC 1.3.3.1) (DHODH) carries out the fourth committed step in the pathway and may also be important for mitochondrial electron transport and oxygen radical metabolism. We report here that the gene encoding this enzyme in humans is located in the chromosomal region 16q22. With the mapping of DHODH, the mapping of all the steps of UMP synthesis is complete. All three genes involved map to different human chromosomes. This information is important in consideration of regulation of UMP synthesis in mammals, including humans.

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Authors and Affiliations

  1. Eleanor Roosevelt Institute, 80206, Denver, Colorado

    Tristan Barnes, Preston Parry, Iris Hart, Carol Jones & David Patterson

  2. Centre de Genetique Moleculaire, C.N.R.S., F 91190, Gif sur Yvette, France

    Michele Minet

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  1. Tristan Barnes
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  2. Preston Parry
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  3. Iris Hart
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  4. Carol Jones
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  5. Michele Minet
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  6. David Patterson
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Barnes, T., Parry, P., Hart, I. et al. Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport, and superoxide generation, to human chromosome region 16q22. Somat Cell Mol Genet 19, 405–411 (1993). https://doi.org/10.1007/BF01232751

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  • DOI: https://doi.org/10.1007/BF01232751

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