Summary
The stimulating action of tolbutamide on insulin secretion presents two components; the first is independent of the presence of glucose in the medium which perfuses the beta cells; the second is, on the contrary, dependent upon glucose. D-mannoheptulose and diazoxide permit the dissociation of these two components; the antagonistic effect of the first exerts itself uniquely on that part of the stimulating action of tolbutamide which is gluco-dependent; on the contrary, the antagonistic effect of the second exerts itself on both phases of the stimulating action of the sulfonamide.
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Loubatières-Mariani, M.M., Loubatières, A.L. & Chapal, J. Analysis of the stimulating action of tolbutamide on the secretion of insulin using mannoheptulose and diazoxide. Diabetologia 9, 152–157 (1973). https://doi.org/10.1007/BF01230696
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DOI: https://doi.org/10.1007/BF01230696