Abstract
In the early years of this century prevailing currents of medical opinion led to the imposition of surgery even more aggressive than the radical mastectomy proposed by Halsted to treat breast cancer. More recently breast conservation surgery has become established but is always flanked by additional local treatment, and often by systemic therapy. Studies conducted in Milan were the first to demonstrate that conservative surgery plus an adjuvant therapy such as radiotherapy is efficacious in treating small-size breast cancer. As the year 2000 approaches it has become clear that breast cancer is curable in a high proportion of cases and attention is turning to improving the aesthetic outcome of the surgery, and to investigating the biological and genetic factors that influence the disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Atkins H, Hayward JL, Klugman DJ, Wayte AB (1972) Treatment of early breast cancer: a report after 10 years of clinical trial. Br Med J 2:423–429
Blichert-Toft M, Rose C, Andersen JA, Overgaard M, Axelsson CK, Andersen KW, Mouridsen HT on behalf of the Danish Breast Cancer Cooperative Group (1992) Danish randomized trial comparing breast conservation therapy with mastectomy: Six years of life-table analysis. J Natl Cancer Inst Monogr 11:19–25
Fisher B, Bauer M, Margolese R, Poisson, R, Pilch Y, Redmond C, Fisher E, Wolmark N, Deutsch M, Montague E, Saffer E, Wickerham L, Lerner H, Glass A, Shibata H, Deckers P, Ketcham A, Oishi R, Russeli I (1985) Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med 312:665–673
Galimberti, V, Zurrida S, Zanini V, Callegari M, Veronesi P, Catania S, Luini A, Greco M, Grisotti A (1993) Central small size breast cancer: how to overcome the problem of nipple and areola involvement. Eur J Cancer 29A: 1093–1096
Ghossein NA, Alpert S, Barba J, Pressman P, Stacey P, Lorenz E, Shulman M, Sadarangani GJ (1992) Breast cancer. Importance of adequate surgical excision prior to radiotherapy in the local control of breast cancer in patients treated conservatively. Arch Surg 127: 411–415
Hirsh J (1927) Radiumchirurgie des Brustkrebses. Dtsch Med Wochenschr 34: 1419–1421
Holland R, Connolly JL, Gelman R, Mravunac M, Hendriks JHCL, Verbeek ALM, Schnitt SJ, Silver B, Boyages J, Harris JR (1990) The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast. J Clin Oncol 8: 113–118
La Vecchia C, Lucchini F, Negri E, Boyle P, Maisonneuve, P, Levi F (1992) Trends of cancer mortality in Europe 1955–1989. III. Breast and genital Sites. Eur J Cancer 28A: 927–998
Lichter AS, Lippman ME, Danforth DN, Angelo Td', Steinberg SM, Moss E de, MacDonald HD, Reichert CM, Merino M, Swain SM, Cowan K, Gerber LH, Bader JL, Findlay PA, Schain W, Gorrell CR, Straus K, Rosenberg SA, Glatstein E (1992) Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute. J Clin Oncol 10: 976–983
Lippman ME (1995) How should we manage breast cancer in the breast, or buddy, can you paradigm? J Natl Cancer Inst 87: 3–4
Sarrazin D, Le MG, Arriagada R, Contesso G, Fontaine F, Spielmann M, Rochard F, Le Chevalier T, Lacour J (1989) Tenyear results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. Radiother Oncol 14: 177–184
Schnitt SJ, Abner A, Gelman R, Connolly JL, Recht A, Duda RB, Eberlein TJ, Mayzel K, Silver B, Harris JR (1994) The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy. Cancer 6: 1746–1751
Uppsala-Örebro Breast Cancer Study Group (1990) Sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Natl Cancer Inst 82: 277–282
Van Dongen JA, Bartelink H, Fentiman IS, Lerut T, Mignolet F, Olthuis G, Van der Schueren E, Sylvester R, Winter J, Van Ziji K (1992) Randomized Clinical Trial to assess the value of breastconserving therapy in stage I and II breast cancer, EORTC 10801 Trial. J Natl Cancer Inst. Monogr 11: 15–18
Veronesi U (1994) How important is the assessment of resection margins in conservative surgery for breast cancer? Cancer 74: 1660–1661
Veronesi U, Saccozzi R, Del Vecchio M, Banfi A, Clemente C, De Lena M, Gallus G, Greco, M, Luini A, Marubini E, Muscolino G, Rilke F, Salvadori B, Zecchini A, Zucali R (1981) Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 305: 6–11
Veronesi U, Volterrani F, Luini A, Saccozzi R, Del Vecchio M, Zucali R, Galimberti V, Rasponi A, Di Re E, Squicciarini P, Salvadori B (1990) Quadrantectomy versus lumpectomy for small size breast cancer. Eur J Cancer 26: 671–673
Veronesi U, Farante G, Galimberti V, Greco M, Luini A, Sacchini V, Andreola S, Leoni F, Menard S, Ronco M (1991) Evaluation of resection margins after breast conservative surgery with monoclonal amtibodies Eur J Surg Oncol 17: 338–341
Veronesi U, Luini A, Del Vecchio M, Greco M, Galimberti V, Merson M, Rilke F, Sacchini V, Saccozzi R, Savio T, Zucali R, Zurrida S, Salvadori B (1992) Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med 328: 1587–1591
Veronesi U, Marubini E, Del Vecchio M, Manzari A, Andreola S, Greco M, Luini A, Merson M, Saccozzi R, Rilke F, Salvadori B (1995) Local recurrences and distant metastases after conservative breast cancer treatments: partly independent events. J Natl Cancer Inst 87: 19–27
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Veronesi, U., Zurrida, S. Breast cancer sugery: a century after Halsted. J Cancer Res Clin Oncol 122, 74–77 (1996). https://doi.org/10.1007/BF01226264
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01226264