Summary
Erythrocyte aggregation, plasma fibrinogen concentrations and serum protein fractions have been studied in 19 diabetic patients without retinopathy, 18 patients with retinopathy and 41 non-diabetic controls. — Significant differences in the parameters were observed between diabetics and controls. The differences between the diabetics with and without retinopathy were not significant. — The role of abnormal erythrocyte aggregation in the development of diabetic retinopathy is discussed. — Striking parallels were found with similar findings concerning platelet aggregation in diabetics.
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Brinkman, R., Zijlstra, W.G. and Jansonius, N.J.: Quantitative evaluation of the rate of rouleaux formation of erythrocytes by measuring light reflection (“syllectometry”). Proc. kon. ned. Akad. Wet.66, 412 (1963).
Chien, S., Usami, S., Dellenback, R.J., Gregersen, M.I., Nanninga, L.B. and Guest, M.M.: Blood viscosity: influence of erythrocyte aggregation. Science157, 829 (1967).
Dintenfass, L., Julian, D. and Miller, G.: Viscosity of blood in normal subjects an in patients suffering from coronary occlusion and arterial thrombosis. Amer. Heart. J.7, 587 (1966).
Ditzel, J. and Moinat, P.: Lipoproteins and glyeoproteins in diabetic subjects. J. Lab. clin. Med.57, 873 (1959).
Haeringen, N.J. van and Glasius, E.: The relation between rouleaux formation in blood and fibrinogen content in plasma. Clin. chim. Acta29, 55 (1970).
Heath, H., Brigden, W.D., Canever, J.V., Pollock, J., Hunter, P.R., Kelsey, J. and Bloom, A.: Platelet adhesiveness and aggregation in relation to diabetic retinopathy. Diabetologia7, 308 (1971).
Hirschboeck, S.: Lecithin and the erythrocyte factor in the blood sedimentation phenomenon. Blood2, 578 (1947).
Jansonius, N.J. and Zijlstra, W.G.: Various factors influencing rouleaux formation of erythrocytes, studied with the aid of syllectometry. Proc. kon. ned. Akad. Wet.68, 121 (1965).
Kampen, E.J. van and Zijlstra, W.G.: Standardisation of haemoglobinometry II. The haemiglobincyanide method. Clin. chim. Acta6, 538 (1961).
Merrill, E.W., Cokelet, G.C., Britten, A. and Wells, R.E.: Non-Newtonian rheology of human blood — Effect of fibrinogen deduced by “subtraction”. Circulat. Res.13, 48 (1963).
Ogston, C.M. and Ogston, D.: Plasma fibrinogen and plasminogen levels in health and in ischaemic heart disease. J. clin. Path.19, 352 (1966).
Oosterhuis, J.A.: Fluorescein fundus photography in retinal vein occlusion. Perspectives in Ophthalmology, p. 29. Rotterdam: (Excerpta Medica Foundation), (1967).
Skovborg, F., Nielsen, Aa.V., Schlichtkrull, J. and Ditzel, J.: Blood-viscosity in diabetic patients. Lancet1966 I, 129.
Thorsen, G. and Hint, H.: Aggregation, sedimentation and intravascular sludging of erythrocytes. Acta chir. scand.154 (1950).
Vink, R.: Fluorescein angiography in diabetic retinopathy. Leiden: Thesis (1969).
Ware, A.G., Guest, M.M. and Seegers, W.H.: Determination of fibrinogen in plasma by applying the biuret reaction to the fibrin clot. Arch. Biochem.13, 231 (1947).
Wells, R.E., Gawronski, T.H., Cox, P.J. and Pepera, R.D.: Influence of fibrinogen on flow properties of erythrocyte suspensions. Amer. J. Physiol.207, 1035 (1964).
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van Haeringen, N.J., Oosterhuis, J.A., Terpstra, J. et al. Erythrocyte aggregation in relation to diabetic retinopathy. Diabetologia 9, 20–24 (1973). https://doi.org/10.1007/BF01225995
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DOI: https://doi.org/10.1007/BF01225995