Summary
The dynamics of paraquat in the stomach and esophagus of rats were demonstrated using immunohistochemical techniques. The Rats were killed 3 h, 12 h, 24 h, 3 days, 7 days and 10 days after intravenous administration of paraquat. In the stomach, paraquat was localized in the epithelial cells between 24h and 10 days after injection, whereas in the esophagus, paraquat was localized in epithelial cells and the lamina propria mucosa between 12 h and 10 days after administration. Although these findings were similar to those observed in the intestine of rats, no clear changes in the distribution of paraquat with time were observed; suggesting that the stomach and esophagus are important reservoirs for the redistribution of paraquat.
Zusammenfassung
Die Verteilung von Paraquat im Gewebe des Magens und des Ösophagus von Ratten wurde mittels immunhistochemischer Verfahren bestimmt. Nach intravenöser Applikation von Paraquat wurden Ratten nach Zeitspannen von 3 h, 12 h, 24 h, 3 Tagen und 10 Tagen getötet. Im Magen wurde Paraquat in den Epithelzellen in einem Zeitraum von 24h bis 10 Tagen nach Applikation gemessen, wohingegen im Ösophagus sowohl in den Epithelzellen als auch in der Lamina propria mucosa Paraquat 12 h bis 10 Tage nach Injektion gemessen werden konnte. Obwohl diese Ergebnisse mit Paraquat-Befunden im Intestinum von Ratten korrelieren, konnte keine eindeutige Zeitabhängigkeit der Verteilung beobachtet werden. Dieses Ergebnis führt zu der Annahme, daß Magen und Ösophagus als wichtige Speichergewebe an einer Redistribution von Paraquat beteiligt sind.
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Nagao, M., Zhang, Wd., Itakura, Y. et al. Immunohistochemical localization and dynamics of paraquat in the stomach and esophagus of rats. Int J Leg Med 106, 142–144 (1993). https://doi.org/10.1007/BF01225235
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DOI: https://doi.org/10.1007/BF01225235