Summary
Two South-West European populations (Galicia and Central Portugal) have been studied for the HLA DQA1 and D1S80 systems. The allele and genotype frequencies found have been compared with other previously published data. The distribution of the observed genotypes is in Hardy-Weinberg equilibrium for both systems. In the D1S80 system, no significant differences were found between both populations, although in the HLA DQA1 system the allele DQA1*0301 is twice as frequent in the Galician population. Other populations that have been compared showed a certain degree of divergence for the HLA DQA1 system. The combined chance of exclusion for both systems is 0.84 in Galicia and 0.85 in Central Portugal, and the combined power of discrimination is 0.993 in the 2 populations studied.
Zusammenfassung
Zwei südwesteuropäische Populationen (Galizien und Zentral-Portugal) wurden auf die Systeme HLA DQA1 und D1S80 untersucht. Die Frequenzen der Allele und der Genotypen wurden mit anderen vorher pulbizierten Daten verglichen. Die Verteilung der beobachteten Genotypen ist bei beiden System im Hard-Weinberg-Gleichgewicht. Im System D1S80 wurden keine signifikanten Unterschiede zwischen beiden Populationen gefunden, obwohl im HAL DQA1-System das Allel DQA1 0301 in der Bevölkerung Galiziens doppelt so häufig ist. Andere Populationen, die verglichen worden sind, zeigen einen bestimmten Grad von Unterschiedlichkeit im HLA DQA1-System. Die kombinierte Ausschlußchance für beide Systeme ist 0,84 in Galizien und 0,85 in Zentral-Portugal und die kombinierte Diskriminations-Kraft ist 0,993 in beiden untersuchten Populationen.
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Laren, M.V., Muñoz, I., Pestonil, C. et al. The distribution of HLA DQA1 and D1S80 (pMCT118) alleles and genotypes in the populations of Galicia and Central Portugal. Int J Leg Med 106, 124–128 (1993). https://doi.org/10.1007/BF01225231
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DOI: https://doi.org/10.1007/BF01225231