Summary
Lactic acidosis is a rare but serious complication of the use of biguanides in anti-diabetic therapy. This report details two cases of diabetic lactic acidosis secondary to Metformin, successfully treated by peritoneal dialysis, using sodium acetate as the dialyzing substance. The author emphasizes the use of extra-renal purification, and more specifically peritoneal dialysis, as symptomatic therapy of lactic acidosis in the diabetic patient. Acetate, rather than lactate, as the dialyzing substance, is most justified from a biochemical point of view.
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Auzepy, Ph., Masliah, R., Pianohon, R., Baulon, A., Lemonier, A., Deparis, M.: Acidose lactique. Importance pronostique du diagnostic precoce. Ann. méd. int.122, 13–20 (1971)
Assan, R.: Acidose lactique. Colloques de Réanimation de l'Hopital Claude Bernard, Arnette Ed., 1971
Attali, J.R.: Contribution à l'étude de l'acidose lactique. I-Analyse physio-pathologique de l'acidose lactique humaine, 2-Etude experimentale du traitement des acidoses lactiques par la dialyse peritoneale chez le rat blanc. Paris: These 1971
Azerad, E., Lubetzki, J., Duprey, J., Friedler, D.: L'acidose lactique chez les diabetiques. A propos de 7 observations. Presse méd.77, 1705–1708 (1969)
Boen, S.T.: Peritoneal dialysis in clinical medicine. In: Kugelmass (ed.). Springfield, Ill.: Thomas Publisher 1964
Mac Gregor, G.A., Boodle-Wilson, P.A., Jones, N.F.: Phenformin and metabolic acidosis. Lancet1972 I, 69–71
Henderson, A.R.: Biochemistry of hypoxia: Current concepts. Brit. J. Anaesth.41, 245–250 (1969)
Jurgesen, J.C.: Dialysis for lactic acidosis. New Engl. J. Med.278, 1350 (1968)
Oliva, P.B.: Lactic acidosis. Amer. J. Med.48, 209–225 (1970)
Tranquada, R.E.: Lactic acidosis. Calif. Med.101, 450–455 (1964)
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Hayat, J.C. The treatment of lactic acidosis in the diabetic patient by peritoneal dialysis using sodium acetate. A report of two cases. Diabetologia 10, 485–487 (1974). https://doi.org/10.1007/BF01221643
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DOI: https://doi.org/10.1007/BF01221643