Summary
The adrenal function of the obese-hyperglycemic mouse has been analysed by measurements of serum corticosteroid levels at different ages and after various types of stimulation. In addition, the corticosteroid binding capacity (CBC) of the serum was evaluated in these animals. The results showed that in all ages investigated the obese hyperglycemic animals had significantly elevated values of serum corticosteroids compared with their lean controls. This difference did not vary with age. Both administration of ACTH and stressful handling further increased the corticosteroid values of the obese animals. In addition, the CBC was significantly elevated in these animals at the ages of 6 and 16 months. Since the serum corticosteroid levels, in contrast to other manifestations of the obese-hyperglycemic syndrome, did not vary with age, it is suggested that the hyperadrenocorticism observed in these animals is not of primary aetiological significance for the development of the syndrome. This does not preclude the possibility that a prolonged elevation of serum corticosteroid levels contributes to the syndrome.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Carstensen, H., Hellman, B., Larsson, S.: Biosynthesis of steroids in the adrenals of normal and obese-hyperglycemic mice. Acta Soc. Med. upsalien.66, 139–151 (1961)
Coleman, D.L.: Effects of parabiosis of obese with diabetes and normal mice. Diabetologia9, 294–298 (1973)
Daughaday, W.H.: Binding of corticosteroids by plasma proteins. III. The binding of corticosteroid and related hormones by human plasma and plasma protein fractions as measured by equilibrium dialysis. J. clin. Invest.37, 511–518 (1958)
DeMoor, P., Steeno, 0., Raskin, M., Hendrikx, A.: Fluorometric determination of free plasma 11-hydroxycorticosteroids in man. Acta endocr. (Kbh.)33, 297–307 (1960)
Eränkö, O.: Quantitative methods in histology and microscopic histochemistry, p. 23. Basel, New York: S. Karger Publishers 1955
Forsham, P.H.: The adrenal cortex.In: Williams, R.H.: Textbook of Endocrinology p. 292. Philadelphia London, Toronto: W.B. Saunders Company, 1968
Halberg, F., Albrecht, P.G., Bittner, J.J.: Corticosterone rhythm of mouse adrenal in relation to serum corticosterone and sampling. Amer. J. Physiol.197, 1083–1085 (1959)
Hausberger, P.X.: Islet hypertrophy in obesity, induced by corticosteroids. Fed. Proc.17, 67 (1958)
Hellerström, C., Hellman, B., Larsson, S.: Some aspects of the structure of the adrenals in obese-hyperglycemic mice. Acta path. microbiol. scand.54, 365–372 (1962)
Hellerström, C., Westman, S., Herbai, G., Petersson, B., Westman, J., Borglund, E., Östenson, C.-G.: Pathogenetic aspects of the obese-hyperglycemic syndrome in mice (genotypeobob): II. Extrahepatic factors. Diabetologia6, 284–291 (1970)
Hjelm, M., DeVerdier, C.H.: A methodological study of the enzymatic determination of glucose in blood. Scand. J. Clin. Lab. Invest.15, 415–428 (1963)
Marshall, M.B., Andrus, S.B., Mayer, J.: Organ weights in three forms of experimental obesity in the mouse. Amer. J. Physiol.189, 343–346 (1957)
Martin, J.M., Mok, C., Hill, D.E., Crowne, D.: A hypothalamic islet stimulating factor. Excerpta Medica, International Congress Series no.280, 67 (1973)
Naeser, P.: Adrenal function in the obese-hyperglycemic syndrome(obob) in mice. Diabetologia9, 83 (1973)
Naeser, P.: Effects of adrenalectomy on the obese-hyperglycemic syndrome in mice (gene symbolob). Diabetologia9, 376–379 (1973)
Naeser, P.:In vitro release of oorticosteroids from adrenal glands of obese-hyperglycemic mice (gene symbolob) Acta physiol. scand. In press.
Scott, J.P.: Methodology and techniques for the study of animal societies. Ann. N.Y. Acad. Sci. 51, Art.6, 1001–1005 (1950)
Slaunwhite, W.B., Sandberg, A.A.: Transcortin; A corticosteroid-binding protein of plasma. J. clin. Invest.38, 384–391 (1959)
Snedecor, G.W.: Statistical methods, fifth ed. Ames, Iowa: The Iowa State College Press 1956
Solem, J.H.: Plasma corticosteroids in mice with special regard to sex difference in adrenocortical responsiveness to exogenous corticotrophin. Scand. J. clin. Lab. Invest. Suppl.93, 1–36 (1966)
Solomon, J., Mayer, J.: The effect of adrenalectomy on the development of the obese-hyperglycemic syndrome inob/ob mice. Endocrinology93, 510–513 (1973)
Trapp, G.A., West, C.D.: Determination of corticosteroid-binding proteins by an adsorption method. J. Lab. clin. Med.73, 861–871 (1969)
Westman, S.: Development of the obese-hyperglycemic syndrome in mice. Diabetologia4, 141–149 (1968)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Naeser, P. Function of the adrenal cortex in obese-hyperglycemic mice (gene symbolob). Diabetologia 10, 449–453 (1974). https://doi.org/10.1007/BF01221636
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01221636