This study was undertaken to analyse metastases of patients with intermediate- or high-grade chondrosarcomas. Out of 24 intermediate-grade tumours, 5 (21%) developed metastases, as did 6 of 10 high-grade tumours (60%) (P=0.04). Four patients developed pulmonary metastasis only, 5 developed both pulmonary metastases and metastases of the other sites. Two patients showed a rare metastatic pattern: bone metastases only. The metastasis rate in the primary chondrosarcoma (42%) was higher than that in the secondary chondrosarcomas (0%) (P=0.03). The metastasis rate was higher in patients with local recurrence (86%) than in those without local recurrence (19%) (P=0.01). In 5 of 6 patients who had a local relapse and metastasis, the interval between the two relapses was a few months.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Abello R, Lomena F, Garcia A, Herranz R, Fernandes SJ, Plaza V, Sole M, Setoain J (1986) Unusual metastatic chondrosarcoma detected with bone scintigraphy. Eur J Nucl Med 12:306–308
Aprin H, Riseborough EJ, Hall JE (1982) Chondrosarcoma in children and adolescents. Clin Orthop 166:226–232
Bauer HC, Brosjö O, Kreicbergs A, Lindholm J (1995) Low risk of recurrence of enchondroma and low-grade chondrosarcoma in extremities. Acta Orthop Scand 66:283–288
Boström H, Edgren B, Friberg U (1968) Case of chondrosarcoma with pulmonary and skeletal metastases after hemipelvectomy successfully treated with 35-S-sulfate. Acta Orthop Scand 39:549–551
Dahlin DC, Unni KK (1986) Chondrosarcoma (primary, secondary, dedifferentiated, and clear-cell). In: Dahlin DC, Unni KK (eds) Bone tumors. General aspects and data on 8542 cases. Thomas, Springfield, pp 227–259
Disler DG, Rosenberg AE, Springfield D, O'Connell JX, Rosenthal DI, Kattapuram SV (1993) Extensive skeletal metastases from chondrosarcoma without pulmonary involvement. Skeletal Radiol 22:595–599
Enneking WF (1986) A system of staging musculoskeletal neoplasms. Clin Orthop 204:9–24
Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 153: 106–120
Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone. A clinicopathologic analysis with emphasis on histologic grading. Cancer 40:818–831
Gitelis S, Bertoni BF, Picci CP, Campanacci M (1981) Chondrosarcoma of bone. The experience at the Instituto Orthopedico Rizzoli. J Bone Joint Surg [Am] 63:1248–1257
Göbel V, Jürgens H, Etspüler G, Kemperdick H, Jungblut RM, Steinen U, Göbel U (1987) Prognostic significance of tumor volume in localized Ewing's sarcoma of bone in children and adolescents. J Cancer Res Clin Oncol 113:187–191
Pritchard DJ, Lunke RJ, Taylor WF, Dahlin DC, Medley B (1980) Chondrosarcoma: a clinicopathologic and statistical analysis. Cancer 45:149–157
Sanerkin NG, Gallagher P (1979) A review of the behavior of chondrosarcoma of bone. J Bone Joint Surg [Br] 61:395–400
Winkler K, Bielack S, Delling G, Salzer-Kuntschik M, Kotz R, Greenshaw C, Jürgens H, Ritter J, Kusnierz-Glaz C, Erttmann R, Gädicke G, Graf N, Ladenstein R, Leyvraz S, Mertens R, Weinel P (1990) Effect of intraarterial versus intravenous cisplatin in addition to systemic doxorubicin, high-dose methotrexate, and ifosfamide on histologic tumor response in osteosarcoma (study COSS-86). Cancer 66:1703–1710
Rights and permissions
About this article
Cite this article
Ozaki, T., Hillmann, A., Lindner, N. et al. Metastasis of chondrosarcoma. J Cancer Res Clin Oncol 122, 625–628 (1996). https://doi.org/10.1007/BF01221195