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The importance of distinguishing “Clinical Judgement” in cancer management from “selection bias” in clinical trials

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References

  • Eddy DM (1992) High-dose chemotherapy with autologous bone marrow transplantation for the treatment of metastatic breast cancer. J Clin Oncol 10: 657–670

    PubMed  Google Scholar 

  • Gianni L, Munzone E, Capri G, Villani F, Spreafico C, Tarenzi E, Fulfaro F, Caraceni A, Martine C, Laffranchi A, Valagussa P, Bonadonna G (1995) Paclitaxel in metastatic breast cancer: a trial of two doses by a 3-hour infusion in patiens with disease recurrence after prior therapy with anthracyclines. J Natl Cancer Inst 87: 1169–1175

    PubMed  Google Scholar 

  • Holmes FA, Walters RS, Theriault RL, Forman AD, Newton LK, Raber MN, Buzdar AU, Frye DK, Hortobagyi GN (1991). J Natl Cancer Inst 87: 1797–1805

    Google Scholar 

  • Karnofsky DA, Burchenal JH (1948) The clinical evaluation of chemotherapeutic agents in cancer.In Evaluation of chemotherapeutic agents, CM Macleod, Ed. New York, Columbia University Press, pp 191–205

    Google Scholar 

  • Rowinsky EK, Donehower RC (1995) Paclitaxel (taxol). N Engl J Med 332: 1004–1013

    PubMed  Google Scholar 

  • Seidman AD, Tiersten A, Hudis C, Gollub M, Barrett S, Yao T-J, Lepore J, Gilewski T, Currie V, Crown J, Hakes T, Baselga J, Sklarin N, Moynihan ME, Tong W, Egorin M, Kearns C, Spriggs D, Norton L (1995) Phase II trial of paclitaxel by 3-hour infusion as initial and salvage chemotherapy for metastatic breast cancer. J Clin Oncol 13: 2575–2581

    PubMed  Google Scholar 

  • Simon R (1984) Importance of prognostic factors in cancer clinical trials. Cancer 68: 185–192

    Google Scholar 

  • Yates JW, Chalmer B, McKegney FP (1980) Evaluation of patients with advanced cancer using the Karnofsky Performance Status. Cancer 45: 2220–2224

    PubMed  Google Scholar 

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The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest editorials” on current and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the authors.

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Markman, M. The importance of distinguishing “Clinical Judgement” in cancer management from “selection bias” in clinical trials. J Cancer Res Clin Oncol 122, 573–574 (1996). https://doi.org/10.1007/BF01221187

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  • DOI: https://doi.org/10.1007/BF01221187

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