Summary
A simple method for the estimation of plasma insulin in the presence of insulin antibodies is described using dilution and dextran-charcoal separation. In 43 non-insulin resistant diabetics the estimated non-extracted (N.E.) insulin was between 69 and 2444 μU/ml. N.E. insulin appears to be constantly related to values obtained by acid-alcohol extraction of plasma containing insulin-antibodies, representing about 60% of total insulin.
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Martin, F.I.R., Russell, J. A simple method for determining plasma insulin in the presence of endogenous insulin antibodies. Diabetologia 10, 93–96 (1974). https://doi.org/10.1007/BF01219662
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DOI: https://doi.org/10.1007/BF01219662