Summary
Plasma growth hormone was measured by radioimmunoassay under basal conditions and after glucose administration in the New Zealand Obese (NZO) mouse and in a control strain. There was greater variability of plasma IRGH in the NZO mice than in the control strain under basal conditions, but there was no significant difference between the mean log plasma IRGH in the two strains. Moreover, in both strains rapid suppression of plasma IRGH occurred following glucose administration. It appears unlikely that pituitary hypersecretion of growth hormone accounts for the metabolic abnormalities observed in the NZO mouse.
Résumé
L'hormone de croissance immunoréactive (IRGH) plasmatique a été mesurée par une méthode radio-immunologique dans des conditions de base et après l'administration de glucose chez la souris obèse de la Nouvelle-Zélande (NZO) et aussi chez une souche de souris témoins. On a constaté plus de variabilité de IRGH plasmatique chez la souris NZO que chez la souche de souris témoins dans les conditions de base, mais il n'y avait pas de différence notable entre la moyenne logarithmique de IRGH plasmatique dans les deux souches de souris. D'ailleurs dans toutes les deux races il y avait une suppression rapide de IRGH plasmatique après l'administration de glucose. Il paraît peu probable que l'hypersécrétion pituitaire de l'hormone de croissance explique les anomalies métaboliques observées chez la souris NZO.
Zusammenfassung
Das Wachstumshormon im Plasma wurde unter Anwendung der Radioimmunomethode unter basalen Bedingungen und nach Zufuhr von Glucose bei der New Zealand obese mouse (NZO) und einer Kontrollzucht gemessen. Unter basalen Bedingungen bestand bei den NZO-Mäusen eine größere Variabilität des immunreaktiven Wachstumshormons im Plasma (IRGH) als bei der Kontrollzucht; es fand sich jedoch kein wesentlicher Unterschied des mittleren logarithmischen Plasma-IRGH bei den beiden Zuchten. Darüberhinaus erfolgte nach Zufuhr von Glucose bei beiden Zuchten eine schnelle Suppression des Plasma-IRGH. Es ist unwahrscheinlich, daß die pituitäre Hypersekretion des Wachstumshormons für die metabolischen Anomalien bei der NZO-Maus verantwortlich zu machen ist.
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Larkins, R.G. Plasma growth hormone in the New Zealand Obese mouse. Diabetologia 7, 302–307 (1971). https://doi.org/10.1007/BF01219462
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DOI: https://doi.org/10.1007/BF01219462