Summary
Nineteen patients, of whom ten had been previously treated with and failed on other oral antidiabetic drugs, were included in a cross-over trial in order to compare the efficacy of glipizide with placebo in the case of the newly diagnosed patients and with previous therapy in established diabetics. Glipizide was more effective than placebo in all cases and provided excellent or good control in eight out of the nine newly diagnosed patients. In three out of the ten previously treated patients, glipizide improved control. The drug was well tolerated.
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Ambrogi, V., Bloch, K., Daturi, S., Griggi, P., Logemann, W., Parenti, M.A., Rabini, T., Tommasini, R.: New oral antidiabetic drugs. Part I., Arzneimittel-Forsch.21, 200–204 (1971)
Ambrogi, V., Bloch, K., Cozzi, P., Daturi, S., Logemann, W., Parenti, M.A., Tommasini, R.: New oral antidiabetic drugs. Part II., Arzneimittel-Forsch.21, 204–208 (1971)
Ambrogi, V., Bloch, K., Daturi, S., Griggi, P., Logemann, W., Mandelli, V., Parenti, M.A., Rabini, T., Usardi, M.M., Tommasini, R.: Pharmacological study on a new oral antidiabetic: N-(4-(β-(5-Methylpyrazine-2-carboxamido)-ethyl)-benzene-sulphonyl)-N'cyclohexyl-urea or K 4024. Arzneimittel-Forsch.21, 208–215 (1971)
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Persson, G. Clinical study with glipizide, a new oral antidiabetic drug. Diabetologia 9 (Suppl 1), 348–350 (1973). https://doi.org/10.1007/BF01218445
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DOI: https://doi.org/10.1007/BF01218445