Summary
Twelve newly diagnosed and eleven previously unsuccessfully treated diabetics were included in a strictly controlled cross-over trial comparing the efficacy of glipizide with that of a placebo or the previous orally administered antidiabetic drug. All newly diagnosed diabetics responded to glipizide and in eleven of them (91%), the control of the glycaemia was “excellent” or “good”. In the cases with severe diabetes, glipizide achieved on an average a better control of the glycaemia due to meals than that produced by the previous therapy. — Neither hypoglycaemia nor side-effects have been observed. We therefore conclude that glipizide is an effective and safe high potency oral sulphonylurea.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Ambrogi, V., Bloch, K., Daturi, S., Griggi, P., Logemann, W., Parenti, M.A., Rabini, T., Tommasini, R.: New oral antidiabetic drugs. Part I. Arzneimittel-Forsch.21, 200–208 (1971)
Ambrogi, V., Bloch, K., Cozzi, P., Daturi, S., Logemann, W., Parenti, M.A., Tommasini, R.: New oral antidiabetic drugs. Part II. Arzneim.-Forsch.21, 200–204 (1971)
Ambrogi, V., Bloch, K., Daturi, S., Griggi, P., Logemann, W., Mandelli, V., Parnnti, M.A., Rabini, T., Usardi, M.M., Tommasini, R.: Pharmacological study of a new oral antidiabetic: N-(4-(β-(5-methyl-pyrazine-2-carboxamido)-ethyl)-benzenesulfonyl)-N′-cyclohexylurea or K 4024; Arzneimittel-Forsch.21, 208–215 (1971)
Ambrogi, V., Artini, D., Fuccella, L.M., Goldaniga, G., Orsini, G., Ronchi, R., Tamassia, V., Valzelli, G., Angelucci, R.: Farmacocinetica e metabolismo in animali da esperimento e nell'uomo della N-4-[β-(5-metilpirazina-2-carbossiamido)-etil]-benzensolfonil)-N′-cicloesil-urea (K 4024). Boll. Chim. Farm.111, 251–264 (1972)
Marigo, S., Del Nevo, G., Bini, P.P., Sacchetti, G.: Pharmacological methods for evaluating a new hypoglycaemic agent in humans: a multistep design. Arzneimittel-Forsch.21, 215–220 (1971)
D'Onofrio, F., Pempinello, R., Romis, L.: Clinical and metabolic observations with a new synthetic oral antidiabetic agent, glipizide; Arzneimittel-Forsch. Drug Res.22, 1879–1881 (1972)
Fedele, D., Tiengo, A., Riva, F., Muggeo, M., Emanueli, A., Crepaldi, G.: Modifications of glycemia and insulinemia in diabetics treated with Glipizide (K 4024), a new sulfonylurea. Arzneimittel-Forsch. (Drug Res.)22, 1885–1888 (1972)
Vailati, G., Pagani, G., Montini, M., Caputo, G., Sacchetti, G.: Effect of glipizide on a double-meal test in diabetic patients; Arzneimittel-Forsch. (Drug Res.)22, 1888–1889 (1972)
Vailati, G., Montini, M., Pagani, G., Caputo, G.: Studio delle modificazioni indotte dalla glidiazinamide sulla tolleranza orale al glucosio in 15 casi di diabete dell'età adulta. Minerva Med.63, 3752–3757 (1972)
Pisani Ceretti, A., Artini, D., Losi, S., Mandelli, V., Emanueli, A.: Ricerche metaboliche in soggetti non diabetici trattati con sulfoniluree ipoglicemizzanti. Gass. med. ital.131, 307–315 (1972)
Artini, D., Abbiati, R., Orsini, G., Parenti, M.A., Bloch, K., Daturi, S., Mandelli, V.: Pharmacodynamic aspects of two sulphonylurea derivatives glipizide and glibenclamide Diabetologia Suppl. to9, 311 (1973)
Loubatières, A.: An experimental study of glipizide. Personal communication
Herchuelz, A., Malaisse, W.J.: Insulinotropic potency of glipizide in vitro. Diabetologia Suppl. to9, 309 (1973)
Marco, J., Valverde, I.: Unaltered glucagon secretion after seven days of sulfonylurea administration in normal subjects. Diabetologia. Suppl. to9, 317 (1973)
Balant, L., Zahn, G., Gorgia, A., Schwarz, R., Fabre, J.: Pharmacokinetics of glipizide in man: Influence of renal insufficiency. Diabetologia Suppl. to9, 331 (1973)
Schmidt, H.A.E., Schoog, M., Schweer, K.-H., Winkler, E.: Pharmacokinetics and pharmacodynamics as well as metabolism following orally and intravenously administered C14-glipizide, a new antidiabetic. Diabetologia Suppl. to9, 320 (1973)
Fuccella, L.M., Tamassia, V., Valzelli, G.: Metabolism and kinetics of the hypoglycaemic agent glipizide in man —comparison with glibenclamide. J. clin. Pharmacol. In press
Greco, A.V., Fedeli, G., Chiranda, G., Lucente, M., Accietto, F., Fenici, R.: Esperienze cliniche sull'azione di un nuovo antidiabetico orale: la glydiazinamide; (Clinical investigation of a new oral antidiabetic drug: glydiazinamide). Minerva med.62, 2829–2839 (1971)
Pedrazzi, F., Pisani Ceretti, A., Losi, S., Bommartini, F., Artini, D., Emanueli, A.: Evaluation in hospitalized subjects of a new hypoglycaemic sulfonylurea, glydiazinamide. Arzneimittel-Forsch.21, 220–225 (1971)
Lentini, S., Bossini, A., Colombo Pirola, L.: A controlled clinical trial of a new oral hypoglycemic agent, glipizide (K 4024) Arzneimittel-Forsch. (Drug Res.),22, 1169–1173 (1972)
Cantera, N.M., Cicconetti, C.A., Liberti, R.: Studio clinico sull'azione ipoglicemizzante antidiabetica della glidiazinamide (K 4024); (Clinical study on the hypoglycaemic antidiabetic action of glydiazinamide (K 4024). Minerva Ospedaliera La Settimana degli Ospedali Il Medico Ospedaliero13, 73–94 (1971)
Emanueli, A., Molari, E., Colombo Pirola, L., Caputo, G.: Glipizide, a new sulfonylurea in the treatment of diabetes mellitus. Arzneimittel-Forsch. (Drug Res.)22, 1881–1885 (1972)
Forattini, C.: Sperimentazione clinica di un nuovo farmaco hypoglicemizzante (glipizide). (Clinical experiment with a new hypoglycaemic drug). Minerva med.63, 3816 (1972)
Parodi, F.A.: Un nuovo antidiabetico orale, la glidiazinamide or K 4024. (A new oral antidiabetic: glidiazinamide or K 4024). Ricerche cliniche. Minerva Osp.13, 238, (1971)
Editorial by the Committee on the use of Therapeutic Agents: Clinical evaluation of drugs for the treatment of diabetes. Diabetes13, 429–431 (1964)
Rull, J.A., Gonzalez-Millan, H., Quibrera, R., Garcia-Viveros, M., Lozano-Castaneda, O.: Overall therapeutic usefulness of glybenclamide, a new hypoglycemic sulfonylurea. Diabetes19, 264–270 (1970)
Carlström, S., Monti, M.: Hypoglykemi vid behandling av diabetes med glibenklamid (Hypoglycaemia in the treatment of Diabetes with Glibenclamide). Läkartidningen70, 1020–1022 (1973)
Gottesbüren, H., Gerdes, H., Littmann, K.-P.: Schwere Hypoglykämien nach Glibenclamid. Verh. dtsch. Ges. inn. Med.76, 433–435 (1970)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Johannessen, A., Fagerberg, S.E. Glipizide, a new oral antidiabetic agent (report of a controlled clinical study in Sweden). Diabetologia 9 (Suppl 1), 339–347 (1973). https://doi.org/10.1007/BF01218444
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01218444