Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer

Abstract

Insulin-like growth factors are potent mitogenic factors in human lung cancer in vitro, acting via specific receptors. Using monoclonal antibodies we demonstrate the expression of insulin-like growth factor receptor I in bronchial epithelial cells of normal lung and in primary lung cancer (22/24 cases), being most prominent in squamous cell carcinoma. Electron microscopy on lung cancer cell lines reveals a distinct reaction pattern on the plasma membrane. Immunoreaction with a specific antibody directed against the insulin-like growth factor receptor II suggests a weak expression in primary lung cancer. Our findings underline the significance of the autocrine pathway of insulin-like growth factors in lung cancer.

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Abbreviations

IGF:

insulin-like growth factor

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Correspondence to U. Kaiser.

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Kaiser, U., Schardt, C., Brandscheidt, D. et al. Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer. J Cancer Res Clin Oncol 119, 665–668 (1993). https://doi.org/10.1007/BF01215985

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Key words

  • Lung cancer
  • Insulin-like growth factor receptors
  • Immunohistology