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Journal of Cancer Research and Clinical Oncology

, Volume 119, Issue 11, pp 665–668 | Cite as

Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer

  • U. Kaiser
  • C. Schardt
  • D. Brandscheidt
  • E. Wollmer
  • K. Havemann
Original Papers Experimental Oncology

Abstract

Insulin-like growth factors are potent mitogenic factors in human lung cancer in vitro, acting via specific receptors. Using monoclonal antibodies we demonstrate the expression of insulin-like growth factor receptor I in bronchial epithelial cells of normal lung and in primary lung cancer (22/24 cases), being most prominent in squamous cell carcinoma. Electron microscopy on lung cancer cell lines reveals a distinct reaction pattern on the plasma membrane. Immunoreaction with a specific antibody directed against the insulin-like growth factor receptor II suggests a weak expression in primary lung cancer. Our findings underline the significance of the autocrine pathway of insulin-like growth factors in lung cancer.

Key words

Lung cancer Insulin-like growth factor receptors Immunohistology 

Abbreviations

IGF

insulin-like growth factor

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • U. Kaiser
    • 1
  • C. Schardt
    • 1
  • D. Brandscheidt
    • 2
  • E. Wollmer
    • 1
  • K. Havemann
    • 1
  1. 1.Abt. Haematologie/OnkologieZentrum Innere MedizinMarburgGermany
  2. 2.Thoraxklinik Heidelberg-RohrbachHeidelbergGermany

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