Skip to main content

Renal tubular acidosis preceding systemic lupus erythematosus


A 10-year-old girl with distal renal tubular acidosis (RTA) for 4 years (adequately treated for 3 years) developed clinical features suggesting systemic lupus erythematosus (SLE) with supprotive laboratory evidence. Whe had heavy proteinuria and a decreased creatinine clearance (CCr). Renal biopsy showed diffuse proliferative and sclerosing glomerulonephritis with severe tubulointerstitial changes. Following treatment with corticosteroids and cyclophosphamide, she had a clinical remission, an increase inC cr and recovery from systemic acidosis. It is likely that distal RTA in this patient was a manifestation of SLE.

This is a preview of subscription content, access via your institution.


  1. Yeung CK, Wong KL, Ng RP, Ng WL (1984) Tubular dysfunction in systemic lupus erythematosus. Nephron 36: 84–88

    PubMed  Google Scholar 

  2. Kozeny GA, Bar W, Bansal VK, Vertuno LL, Fresco IR, Robinson J, Hano JE (1987) Occurrence of renal tubular dysfunction in lupus nephritis. Arch Intern Med 147: 891–895

    PubMed  Google Scholar 

  3. De Fronzo RA, Cooke CR, Goldberg M, Cox M, Myers AR, Agus ZS (1977) Impaired renal tubular potassium secretion in systemic lupus erythematosus. Ann Intern Med 86: 268–271

    PubMed  Google Scholar 

  4. Caruana RJ, Barish CF, Buckalew VM Jr (1985) Complete distal renal tubular acidosis in systemic lupus: clinical and laboratory findings. Am J Kidney Dis 6: 59–63

    PubMed  Google Scholar 

  5. Appel BG, Silva FG, Pirani CL, Meltzer JI, Estes D (1978) Renal involvement in systemic lupus erythematosus: a study of 56 patients emphasising histologic classification. Medicine (Baltimore) 57: 371–410

    Google Scholar 

  6. Talal N, Zisman E, Shur PH (1968) Renal tubular acidosis, glomerulonephritis and immunologic factors in Sjogren's syndrome. Arthritis Rheum 11: 774–786

    PubMed  Google Scholar 

  7. Ter Borg EJ, Song PE de, Meifer SS, Kallenberg CGM (1991) Tubular dysfunction in proliferative lupus nephritis. Am J Nephrol 11: 16–22

    PubMed  Google Scholar 

  8. Brentjens JR, Sepulveda M, Baliah T, Bentzel C, Erlanger BC, Elwood LC, Montes M, Hsu KC, Andres GA (1975) Interstitial immune complex nephritis in patients with systemic lupus erythematosus. Kidney Int 7: 342–350

    PubMed  Google Scholar 

  9. Park MH, Agati VD, Appel GB Pirani CL (1986) Tubulointerstitial disease in lupus nephritis: relationship to immune deposits, interstitial inflammation, glomerular changes, renal functions, and prognosis. Nephron 44: 309–319

    PubMed  Google Scholar 

  10. Gur H, Kopolovic Y, Gross DJ (1987) Chronic predominant interstitial nephritis in a patient with systemic lupus erythematosus. Ann Rheum Dis 46: 617–623

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bagga, A., Jain, Y., Srivastava, R.N. et al. Renal tubular acidosis preceding systemic lupus erythematosus. Pediatr Nephrol 7, 735–736 (1993).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI:

Key words

  • Distal renal tubular acidosis
  • Systemic lupus crythematosus