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Renal tubular acidosis preceding systemic lupus erythematosus

Abstract

A 10-year-old girl with distal renal tubular acidosis (RTA) for 4 years (adequately treated for 3 years) developed clinical features suggesting systemic lupus erythematosus (SLE) with supprotive laboratory evidence. Whe had heavy proteinuria and a decreased creatinine clearance (CCr). Renal biopsy showed diffuse proliferative and sclerosing glomerulonephritis with severe tubulointerstitial changes. Following treatment with corticosteroids and cyclophosphamide, she had a clinical remission, an increase inC cr and recovery from systemic acidosis. It is likely that distal RTA in this patient was a manifestation of SLE.

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Bagga, A., Jain, Y., Srivastava, R.N. et al. Renal tubular acidosis preceding systemic lupus erythematosus. Pediatr Nephrol 7, 735–736 (1993). https://doi.org/10.1007/BF01213337

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  • DOI: https://doi.org/10.1007/BF01213337

Key words

  • Distal renal tubular acidosis
  • Systemic lupus crythematosus