Radiation and Environmental Biophysics

, Volume 23, Issue 3, pp 213–222 | Cite as

Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status

  • J. V. Moore
  • H. A. Hopkins
  • W. B. Looney


Tumour cords have been examined quantitatively in two rat hepatomas, 3924A and H-4-II-E, that differ in their radiobiological oxygenation status (oxygen enhancement ratio for growth delay [tumour clamped: tumor ‘in air’] was 1.35 for 3924A and only 1.08 for H-4-II-E). The average thickness of tumour cords in 3924A was 118 µm and only 69 µm in H-4-II-E. The migration rates across the cords of the two tumours were approximately the same (1.7 and 1.4 µm ⋅ h−1) but for any given distance from the subtending blood vessel, the proportion of histologically-dead cells within the cord was always higher for H-4-II-E. Volume for volume, H-4-II-E contained four times as much vascular space as 3924A but it is suggested that the poorquality of this vasculature in H-4-II-E contributed to its relative radioresistance.


Oxygen Blood Vessel Migration Rate Average Thickness Oxygenation Status 
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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. V. Moore
    • 1
  • H. A. Hopkins
    • 2
  • W. B. Looney
    • 2
  1. 1.Paterson LaboratoriesChristie Hospital and Holt Radium InstituteManchesterEngland
  2. 2.Division of Radiobiology and BiophysicsUniversity of Virginia Medical SchoolCharlottesvilleUSA

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