Advertisement

Radiation and Environmental Biophysics

, Volume 23, Issue 3, pp 171–177 | Cite as

Microscopic dose distribution around PuO2 particles in lungs of hamsters, rats, and dogs

  • J. H. Diel
  • J. A. Mewhinney
  • R. A. Guilmette
Article

Summary

Syrian hamsters, Fischer rats and Beagle dogs inhaled mono-disperse aerosols of PuO2 and were scarificed during the first 16 days after exposure. The microscopic distribution of radiation dose and tissue-at-risk to alpha irradiation around individual particles in lung was studied using autoradiographs of lung tissue sections. The dose distributions in dogs and rats were more diffuse than in hamsters. A slightly greater tumor incidence was calculated for rats and dogs than for hamsters on the basis of dose distribution using the same dose-effect model for all three species. The small differences in tumor incidence predicted on this basis do not explain the extremely large differences in tumor incidences observed in these species after inhalation of PuO2.

Keywords

Radiation Dose Small Difference Tissue Section Lung Tissue Dose Distribution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Diel JH (1978) Local dose to lung tissue from inhaled238PuO2 particles. Radiat Res 75: 348–372Google Scholar
  2. Diel JH, Mewhinney JA, Snipes MB (1981) Distribution of inhaled238PuO2 particles in Syrian hamster lungs. Radiat Res 88: 299–312Google Scholar
  3. Diel JH, Mewhinney JA (1983) Lung tumor induction in Syrian hamsters with internally deposited particulate Pu: A synthesis based on microscopic dose distribution. Radiat Environ Biophys 22: 251–268Google Scholar
  4. LaFuma J, Nenot JC, Morin M, Masse R, Metivier H, Nolibe D, Skupinski W (1974) Respiratory carcinogenesis in rats after inhalation of radioactive aerosols of actinides and lanthanides in various physicochemical forms. In: Karbe E, Park JF (eds) Experimental lung cancer. Carcinogenesis and bioassays. Springer, Berlin Heidelberg New York, pp 443–453Google Scholar
  5. Park JF, Bair WJ, Busch RH (1972) Progress in beagle dog studies with transuranium elements at Battelle-Northwest. Health Phys 22: 803–810Google Scholar
  6. Rhoads K, Mahaffey JA, Sanders CL (1982) Distribution of inhaled239PuO2 in rat and hamster lung. Health Phys 42: 645–656Google Scholar
  7. Sanders CL, Dagle GE, Cannon WC, Craig DK, Powers GJ, Meier DM (1976) Inhalation carcinogenesis of high-fired239PuO2 in rats. Radiat Res 68: 349–360Google Scholar
  8. Sanders CL, Dagle GE, Cannon WC, Powers GJ, Meier DM (1977) Inhalation carcinogenesis of high-fired238PuO2 in rats. Radiat Res 71: 528–546Google Scholar
  9. Scott BR (1981) A dose-response model for estimating lifetime tumor risks when cell killing occurs. Bull Math Biol 43: 487–501Google Scholar
  10. Weibel ER (1963) Morphometry of the human lung. Academic Press, New York, pp 25, 55Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. H. Diel
    • 1
  • J. A. Mewhinney
    • 1
  • R. A. Guilmette
    • 1
  1. 1.Inhalation Toxicology Research InstituteLovelace Biomedical and Environmental Research InstituteAlbuquerqueUSA

Personalised recommendations