Abstract
We showed previously that the Rb+ transport rate in bone marrow cells (BMC) of vitamin-E-deficient mice is significantly lower than that in BMC of euvitaminotic mice. It is now evident that 4 h after whole-body, low-dose (0.01–1.0 Gy) gamma-irradiation of avitaminotic mice, there is an increase in the rate of Rb+ transport. This increase is quite pronounced, exceeding at all dose levels the rate of Rb+ transport in euvitaminotic mice exposed to the same radiation dose.
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References
Altman KI, Mühlensiepen M, Muzik O, Feinendegen LE (1989) Cation transport by bone marrow cells from vitamin-E-deficient mice. Naturwissensch 76:78–80
Bakkeren JAJM, Bonting SL (1968) Studies on (Na+-K+)-ATPase. XX. Properties of (Na+-K+)-activated ATPase in rat liver. Biochem Biophys Acta 150:460–466
Burton GW, Joyce A, Ingold KU (1983) Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Arch Biochem Biophys 221:281–290
Condy RP, Smith JK (1985) Applied statistics and the SAS programming language. North-Holland, Amsterdam
Edwards JC, Chapman D, Cramp WA, Yatvin MB (1984) The effects of ionizing radiation on biomembrane structure and function. Progr Biophys Mol Biol 43:71–93
Feinendegen LE, Mühlensiepen H, Lindberg C, Marx J, Porschen W, Booz J (1984) Acute and temporary inhibition of thymidine kinase in mouse bone marrow cells after low-dose exposure. Int J Radiat Biol 45:205–215
Feinendegen LE, Mühlensiepen H, Bond VP, Sondhaus CA (1987) Intracellular stimulation of biochemical control mechanisms by low-dose, low-LET irradiation. Healthy Phys 52:663–669
Feinendegen LE, Bond VP, Booz J, Mühlensiepen H (1988) Biochemical and cellular mechanisms of low-dose effects. Int J Radiat Biol 53:23–37
Fonck K, Konings AWT (1978) The effect of vitamin E on cellular survival after X irradiation of lymphoma cells. Br J Radiol 51:832–833
Forbush B III (1988) Rapid86Rb release from an occluded state of the Na, K-pump reflects the rate of dephosphorylation or dearsenylation. J Biol Chem 263:7961–7969
Glynn IM, Richards DE (1982) Occlusion of rubidium ions by the sodium-potassium pump: its implications for the mechanism of potassium transport. J Physiol 330:17–43
Hoffer A, Roy RM (1975) Vitamin E decreases erythrocyte fragility after whole-body irradiation. Radiat Res 61:439–443
Hohn-Elkarim K, Mühlensiepen H, Altman KI, Feinendegen LE (1990) Modification of effects of radiation on thymidine kinase. Int J Radiat Biol 58:97–110
Jθrgensen PL (1982) Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+-K+)-ATPase. Biochim Biophys Acta 694:27–68
Konings WWT, Drijver EB (1979) Radiation effects on membranes. I. Vitamin E deficiency and lipid peroxidation. Radiat Res 80:494–501
Konings WWT, Trieling WB (1977) Inhibition of DNA synthesis in vitamin-E-depleted lymphosarcoma cells by X rays and cytostatics. Int J Radiat Biol 31:397–400
Lewis SE, Wills ED (1962) The destruction of -SH groups of proteins and amino acids by peroxides of unsaturated fatty acids. Biochem Pharmacol 11:901–912
Lucy JA (1972) Functional and structural aspects of biological membranes: a suggested structural role for vitamin E in the control of membrane permeability and stability. Ann NY Acad Sci 203:4–11
Lussier DM, Roy RM (1977) Distribution of vitamin E among tissues and subcellular fractions in sublethally irradiated mice. Radiat Res 70:236–240
Machlin LJ, Bendich A (1987) Free radical tissue damage: protective role of antioxidant nutrients. Fed Am Soc Exp Biol J 1:441–445
Prince EW, Little JB (1973) The effect of dietary fatty acids and tocopherol on the radiosensitivity of mammalian erythrocytes. Radiat Res 53:49–64
Schwenke K (1989) Wirkung von kleinen Strahlendosen and induziertem Vitamin-E-Mangel auf Oxidation von Membranlipiden in Knochenmarkzellen der Maus. Dissertation, University of Bonn, pp 1–72
Taylor SL, Lambden MP, Tappel A (1976) A sensitive fluorometric method for tissue tocopherol analysis. Lipids 11:265–275
Wolters H, Konings AWT (1982) Radiation effects on membranes. III. The effect of X irradiation on survival of mammalian cells substituted by polyunsaturated fatty acids. Radiat Res 92:474–482
Zamboglou M, Porschen W, Mühlensiepen H, Booz J, Feinendegen LE (1981) Low dose effect of ionizing radiation on incorporation of iododeoxyuridine into bone marrow cells. Int J Radiat Biol 39:83–93
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On leave from the University of Rochester, School of Medicine and Dentistry, Department of Biophysics, Rochester, New York, USA
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Altman, K.I., Mühlensiepen, H., Wolters, R. et al. Rubidium transport in irradiated vitamin-E-deficient bone marrow cells. Radiat Environ Biophys 32, 59–64 (1993). https://doi.org/10.1007/BF01213131
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DOI: https://doi.org/10.1007/BF01213131