Summary
A syndrome of diabetes, which appears to be dependent upon diet, is described in an Argentine rodent, the tuco-tuco. Hyperglycaemia and cataract are shown to be inversely related to age and associated with excess mortality. Pancreatic islet, renal glomerular and lens changes are similar to those of human diabetics. It is suggested that this species forms a useful model of human maturity onset diabetes.
Résumé
Les auteurs décrivent un syndrome diabétique, qui semble dépendre du régime, chez un rongeur d'Argentine, le tuco-tuco. - L'hyperglycémie et la cataracte sont en relation inverse avec l'âge et sont associées à un excès de mortalité. Les modifications des îlots pancréatiques, des glomérules rénaux et du cristallin sont semblables à celles observées chez les diabétiques humains. - Il est suggéré que cette espèce constitue un modèle utile pour le diabète humain de la maturité.
Zusammenfassung
Bei einem argentinischen Nagetier, dem Tuco-Tuco, wird ein Diabetessyndrom beschrieben, das von der Nahrungszufuhr abhängig zu sein scheint. Hyperglykämie und Katarakt scheinen in umgekehrter Beziehung zum Alter zu stehen. Sie sind mit erhöhter Mortalität verbunden. Die Veränderungen am Inselapparat, am Pankreas, an den Glomerula der Niern und an der Linse sind ähnlich wie beim menschlichen Diabetes.- Es wird betont, daß diese Species mit Vorteil als Modell für den menschlichen, spät-manifesten Diabetes angesehen werden kann.
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References
Meir, H.: Diabetes mellitus in animals: a review. Diabetes9, 485–489 (1960).
Wilkinson, J.S.: Spontaneous diabetes in domestic animals. Vet. Rev. Annot.3, 69–96 (1957).
Schmidt-Nielsen, K., Haines, H.B., Hackel, D.E.: Diabetes mellitus in the sand rat induced by standard laboratory diets. Science143, 689–690 (1964).
Gonet, A.E., Mougin, J., Renold, A.E.: Hyperplasia and hypertrophy of the islets of Langerhans, obesity and diabetes in the mouse (Acomys dimidiatus). Acta endocr. Suppl.100, 135 (1965).
Rabb, G.B., Getty, R.E., Williamson, W.M., Lombard, L.S.: Spontaneous diabetes in tree shrews (Urogale everetti). Diabetes15, 327–330 (1966).
Wise, P.H., Weir, B.J., Hime, J.M., Forrest, E.: Implications of hyperglycaemia and cataract in a colony of tuco-tucos (Ctenomystalarum). Nature (Lond.)219, 1374–1376 (1968).
Weir, B.J.: A trapping technique for tuco-tucos, Ctenomys talarum. J. Mammal.52, 836–839 (1971).
Riley, V.: Adaptation of orbital bleeding technique to rapid serial blood studies. Proc. Soc. Exp. Biol.104, 751–754 (1960).
Whichelow, M.J., Wigglesworth, A., Cox, B.D., Butterfleld, W. J.H., Abrams, M.E.: Critical blood sugar measurements in diabetes detection and diagnosis. Diabetes16, 219–226 (1967).
Weir, B.J.: Reproduction in a colony of diabetic tucotucos (Ctenomys talarum). In preparation.
Hackel, D.E., Schmidt-Nielsen, K., Haines, H.B., Mikat, E.: Diabetes mellitus in the sand rat: Pathological studies. Lab. Invest.14, 200–207 (1965).
Pictet, R., Orci, L., Gonet, E.A., Rouiller, C., Renold, A.E.: Ultrastructural studies of the hyperplastic islets of Langerhans of spiny mice (Acomys cahirinus) before and during hyperglycaemia. Diabetologia3, 188–211 (1967).
Quay, W.B.: Pancreatic islets of desert rodents. Am. Mid. Nat.64, 342–348 (1960).
Sperber, I.: Studies on the mammalian kidney. Zoologiska Bidrag fran Uppsala22, 249–431 (1944).
Huckel, S.: Eigenautge Glomerulus Veränderungen bes Benigner nephroshlerose. Verh. dtsch. path. Ges.31, 392–397 (1938).
Anderson, G.S.: The pathogenesis of diabetic glomemlosclerosis. J. Path. Bact.67, 241–245 (1954).
Darwin, C.: Journal of a voyage round the world, pp. 69–71. London: Nelson & Sons 1890.
Talice, R.V., Momigliano, E.: La vision del roedor Ctenomys torquatus. Archives Soc. Biol. Montevideo21, 173–178 (1951).
Patterson, J.M.: Diabetic cataracts: a review of experimental studies. Diabetes5, 93–97 (1956).
Charalampous, F.C., Hagstedt, D.M.: Effect of age and diet on development of cataracts in the diabetic rat. Amer. J. Physiol.161, 540–544 (1950).
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Endocrine Unit, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000
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Wise, P.H., Weir, B.J., Hime, J.M. et al. The diabetic syndrome in the tuco-tuco (Ctenomys talarum). Diabetologia 8, 165–172 (1972). https://doi.org/10.1007/BF01212256
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DOI: https://doi.org/10.1007/BF01212256