Summary
D-glucose-U-14C incorporation into arterial lipidsin vitro was greater (p<0.025) in control than in streptozotocin-treated (65 mg/kg) rats. A significant positive correlation between this effect and the plasma immunoreactive insulin levels was achieved, although there was no correlation with the blood glucose levels. It is suggested that the state of circulating insulin in the animal is important in modifying arterial lipid metabolism independent of changes in serum lipids.
Résumé
L'incorporation du D-glucose-U-14C dans les lipides des artèresin vitro était plus grande (p<0.025) chez les témoins que chez les rats traités à la streptozotocine (65 mg/kg). Une corrélation positive et significative entre cet effet et les taux de l'insuline immunoréactive du plasma a été réalisée, bien qu'il n'y ait aucune corrélation avec les taux du glucose sanguin. On suggère que le taux de l'insuline circulant dans l'animal est important par le fait qu'il modifie le métabolisme des lipides des artères indépendamment des changements dans les lipides du sérum.
Zusammenfassung
Die Inkorporation von D-U-14C-Glucose in die Lipide der Arterien warin vitro bei den Kontrolltieren höher (p < 0,025) als bei den mit Streptozotozin (65 mg/kg) behandelten Ratten. Eine signifikant positive Korrelation konnte zwischen diesem Effekt und dem immunologisch reaktiven Plasmainsulin gefunden werden, obgleich keine Korrelation mit den Blutzuckerwerten bestand. Es wird angenommen, daß die Menge des im Tier zirkulierenden Insulins wesentlich ist, um den arteriellen Lipidmetabolismus unabhängig von den Veränderungen der Serumlipide zu beeinflussen.
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Stout, R.W., Buchanan, K.D. & Vallance-Owen, J. Arterial lipid metabolism in relation, to blood glucose and plasma insulin in rats with streptozotocin-induced diabetes. Diabetologia 8, 398–401 (1972). https://doi.org/10.1007/BF01212166
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DOI: https://doi.org/10.1007/BF01212166