Summary
Platelet adhesiveness and the levels of two coagulation factors, fibrinogen and factor VIII, were studied in a series of diabetic and nondiabetic control subjects. All three measurements were significantly abnormal in the diabetic patients. The increase in platelet adhesiveness was capable of distinguishing the diabetics on a group basis, but not on individual results. The greatest increase in platelet adhesiveness was demonstrated in patients with ischaemic heart disease and diabetes. Increased platelet adhesiveness was seen in individuals of both diabetic and control groups, in whom no clinical or electrocardiographic evidence of ischaemic heart disease was found. This finding is discussed, also the relationship between platelet adhesiveness levels and the age, sex, duration of disease, blood glucose and serum lipid levels of the diabetic patients.
Résumé
L'adhésivité des plaquettes et les taux de deux facteurs de coagulation, le fibrinogène et le facteur VIII, ont été étudiés chez un groupe de diabétiques et chez des sujets témoins. Les trois mesures étaient significativement anormales chez les sujets diabétiques. L'augmentation de l'adhésivité des plaquettes permettait de distinguer les diabétiques sur une base de groupe, mains non d'après des résultats individuels. L'augmentation la plus grande de l'adhésivité des plaquettes a été démontrée chez les sujets atteints de maladie de coeur ischémique et de diabète. Une adhésivité accrue des plaquettes a été observée à la fois chez des individus du groupe diabétique et du groupe témoin, chez lesquels on n'a trouvé aucun signe clinique ou électrocardiographique de maladie de coeur ischémique. Ce résultat est discuté, ainsi que la relation entre les taux d'adhésivité des plaquettes et l'âge, le sexe, la durée de la maladie, la glycémie et les taux de lipides du sérum chez les sujets diabétiques.
Zusammenfassung
Die Plättchen-Adhäsivität und die Spiegel zweier Coagulations-Faktoren, Fibrinogen und Faktor VIII wurden bei einer Serie von Diabetikern und nichtdiabetischen Vergleichspersonen untersucht. Die Zunahme der Thrombocyten-Adhäsivität ließ eine Abgrenzung der Diabetiker als Kollektiv, nicht aber für Einzelpersonen zu. Der stärkste Anstieg der PlättchenAdhäsivität fand sich bei Diabetikern mit coronarer Minderdurchblutung. Ein solcher Anstieg ließ sich aber auch bei Diabetikern und Vergleichspersonen nachweisen, bei denen keine klinischen oder elektrokardiographischen Zeichen einer ischämischen Herzerkrankung bestanden. Dieser Befund wird diskutiert ebenso wie die Beziehungen zwischen Thrombocyten-Adhäsivität und Alter, Geschlecht, Krankheitsdauer, sowie Blutzuckerund Blutfettspiegeln der Diabetiker.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Albrink, M.J., Lavietes, P.H., Man, E.B.: Vascular disease and serum lipids in diabetes mellitus. Ann. intern. Med.58, 305–323 (1963).
Bell, E.T.: A postmortem study of vascular disease in diabetes. Arch. Path.53, 444–455 (1952).
Brecher, G., Cronkite, E.P.: Morphology and enumeration of human blood platelets. J. appl. Physiol.3, 365–377 (1950).
Breddin, von K.: Über die gesteigerte Thrombocytenagglutination bei Gefäßkrankheiten. Schweiz med. Wschr.95, 655–660 (1965).
Bridges, J.M., Dalby, A.M., Millar, J.H.D., Weaver, J.A.: The effect of D-glueose on platelet stickiness. Lancet1964 I, 75–77.
Eakins, D.: Studies in atherosclerosis. M.D. Thesis, The Queen's University of Belfast (1963).
Eastham, R.D., Morgan, E.H.: Plasma fibrinogen levels in coronary artery disease. Lancet1963 II, 1196–1197.
Egeberg, O.: The blood coagulability in diabetic patients. Scand. J. clin. Lab. Invest.15, 533–538 (1963).
Feamley, G.R., Chakrabarti, R., Avis, P.R.D.: Blood fibrinolytic activity in diabetes mellitus and its bearing on ischaemic heart disease and obesity. Brit. med. J.1963 I, 921–923.
Glynn, M.F., Murphy, E.A., Mustard, J.F.: Platelets and thrombosis (editorial). Ann. intern. Med.64, 715–719 (1966).
Goldenberg, S., Alex, M., Blumenthal, H.T.: Sequelae of arteriosclerosis of the aorta and coronary arteries. Diabetes7, 98–108 (1958).
Ham, J.M., Slack, W.W.: Platelet adhesiveness after surgery. Brit. J. Surg.54, 385–389 (1967).
van Handel, E., Zilversmit, D.B.: Micromethod for direct estimation of serum triglyceride. J. Lab. clin. Med.50, 152–157 (1957).
Hellem, A.J.: The adhesiveness of human blood platelets in vitro. Scand. J. clin. Lab. Invest.12, Suppl. 51, 1–117 (1960).
—, Skalhegg, B.A., Odegaard, A.B.: The platelet adhesiveness in plasma from diabetic and lipemic patients. Sangre (Barcelona)9, 175–177 (1964).
Hirsch, J., McBride, J.A., Wright, H.P.: Platelet adhesiveness: A comparison of the rotating bulb and glass bead column methods. Thrombos. Diathes. haemorrh. (Stuttg.)16, 100–104 (1966).
—, McBride, J.A.: Increased platelet adhesiveness in recurrent venous thrombosis and pulmonary embolism. Brit. med. J.1965 II, 797–799.
Hoffman, W. S.: Rapid photoelectric method for determination of glucose in blood and urine. J, biol. Chem.120, 51–55 (1937).
Katz, A.M., McDonald, L., Davies, B., Edgill, M.: Fibrinolysis and blood coagulation in ischaemic heart disease. Lancet1963 I, 801–805.
LeCompte, P.M.: Vascular lesions in diabetes mellitus. J. chron. Dis.2, 178–219 (1955).
Marks, H.H.: Longevity and mortality of diabetics. Amer. J. publ. Hlth.55, 416–423 (1965).
McDonald, L., Edgill, M.: Dietary restriction and coagulability of the blood in ischaemic heart disease. Lancet1958 I, 996–998.
— —: Changes in the coagulability of the blood or during various phases of ischaemic heart disease. Lancet1959 I, 1115–1118.
Mitchell, J.R.A., Schwartz, C.J.: In: Arterial Disease-Blackwell Scientific Publications Ltd. (1965).
Murphy, E.A., Mustard, J.F.: Coagulation tests and platelet economy in atherosclerotic and control subjects. Circulation25, 114–125 (1962).
O'Brien, J.R.: The mechanism and prevention of platelet adhesion and aggregation considered in relation to arterial thrombosis. Blood24, 309–314 (1964).
Ogston, CM., Ogston, D.: Plasma fibrinogen and plasminogen levels in health and ischaemic heart disease. J. clin. Path.19, 352–356 (1966).
Owren, P.A.: Coronary thrombosis: its mechanism and possible prevention by linolenic acid. Ann. intern. Med.63, 167–184 (1965).
Philip, R.B., Wright, H.P.: Effect of adenosine on platelet adhesiveness in fasting and lipaemic bloods. Lancet1965 II, 208–209.
Pitney, W.R.: The assay antihaemophilic globulin in plasma. Brit. J. Haemat.2, 250–254 (1956).
Root, H.F., Bland, E.F., Gordon, W.H., White, P.D.: Coronary atherosclerosis in diabetes mellitus. J. Amer, med. Ass.113, 27–30 (1939).
Stearns, S., Schlesinger, M.J., Ruby, A.: Incidence and clinical significance of coronary artery disease in diabetes mellitus. Arch, intern. Med.80, 463–474 (1947).
Wright, Helen P.: The adhesiveness of blood platelets in normal subjects with varying concentrations of anticoagulants. J. Path. Bact.53, 255–262 (1941).
—: Changes in adhesiveness of blood platelets following parturition and surgical operations. J. Path. Bact.54, 461–468 (1942).
Zlatkis, A., Zak, B., Boyle, A.J.: New method for direct determination of cholesterol. J. Lab. clin Med.41, 486–492 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mayne, E.E., Bridges, J.M. & Weaver, J.A. Platelet adhesiveness, plasma fibrinogen and factor VIII levels in diabetes mellitus. Diabetologia 6, 436–440 (1970). https://doi.org/10.1007/BF01212078
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01212078