Skip to main content
SpringerLink
Log in

Mucin-producing bile duct carcinoma originating at the hepatic hilus

  • Case Reports of Interest
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

We describe a mucin-producing bile duct carcinoma that was resected and analyzed pathologically. Endoscopic retrograde cholangiography disclosed amorphous filling defects in the dilated extrahepatic bile duct, suggesting that a large amount of mucin was excreted from the tumor. An intraductal amorphous filling defect showed shape change at different examination times. Pathology examination revealed a papillary tumor which showed mucus production, in the right hepatic duct. The cut section of the resected specimen showed a protuberant papillary lesion, measuring 14×14mm in diameter, forming a cystic mucous lake within the duct wall. Many cancer cells were also found in the mucous lake, the contents of which were strongly positive for mucin stain. The mucous lake developed laterally and communicated with the peribiliary glands, suggesting that the tumor had originated in these glands.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yamada M, Kozuka S, Yamao K, Nakazawa S, Naitoh Y, Tsukamoto Y (1991) Mucin-producing tumor of the pancreas. Cancer 68:159–168

    PubMed  Google Scholar 

  2. Rickaert F, Cremer M, Deviere J, Tavares L, Lambilliotte JP, Schroder S, Wurbs D, Kloppel G (1991) Intraductal mucinhypersecreting neoplasms of the pancreas. Gastroenterology 101:512–519

    PubMed  Google Scholar 

  3. Hirota M, Tomioka T, Shigaki N, Ohshima H, Yamasaki K, Kawakami T, Atari E (1996) A case of mucin-producing intraductal papillary adenocarcinoma (minimally invasive type) which showed extensive intraductal spread (in Japanese). Tan to Sui (J Bil Tract Pancr) 17:11–15

    Google Scholar 

  4. Kokubo T, Itai Y, Ohtomo K, Itoh K, Kawauchi N, Minami M (1988) Mucin-hypersecreting intrahepatic biliary neoplasms. Radiology 168:609–614

    PubMed  Google Scholar 

  5. Bhuiya MMR, Nimura Y, Hayakawa N, Kamiya J, Kondo S, Iyomasa S, Shionoya S (1992) An unusual growth pattern of a mucin-producing intrahepatic cholangiocellular carcinoma involving the hepatic hilus. Hepatogastroenterology 39:66–69

    PubMed  Google Scholar 

  6. Sheen PC, Ker CG, Lee KT, Chien CH, Lin HJ (1986) Obstructive jaundice caused by mucus-secreting adenocarcinoma of major intrahepatic bile ducts. Kaohsiung J Med Sci 2:472–477

    Google Scholar 

  7. Nagino M, Nimura Y, Hayakawa N, Kamiya J, Shionoya S, Fukatu T, Fukuda S (1990) A clinicopathological study of mucusproducing bile duct carcinoma (in Japanese with English abstract). J Jpn Surg Soc 91:695–704

    Google Scholar 

  8. Japanese Society of Biliary Surgery (1993) General rules for surgical and pathological studies on cancer of biliary tract. Kanehara Shuppan, Tokyo, pp 7–12

    Google Scholar 

  9. Kubo S, Ohta Y, Tsukamoto Y (1991) A case of mucus-producing cholangiocarcinoma visualized like choledocholithiasis (in Japanese). Rinshogazou (Clinical Imagiology) 7:126–129

    Google Scholar 

  10. Ishak KG, Willis GW, Cummins SD, Bullock AA (1977) Biliary cystadenoma and cystadenocarcinoma. Cancer 38:322–338

    Google Scholar 

  11. Mizumoto R, Kawarada Y, Taoka H (1991) A new classification of cystic malignant tumours of the liver: Classification of 65 cases reported at the 26th Annual Meeting of the Liver Cancer Society of Japan. J Gastroenterol Hepatol 6:400–407

    PubMed  Google Scholar 

  12. Kawarada Y, Taoka H, Mizumoto R (1991) A report of five cases of cystic bile duct carcinoma of the liver and proposal for a new classification. Gastroenterol Jpn 26:80–89

    PubMed  Google Scholar 

  13. Tomioka T, Tajima Y, Inoue K, Fukahori T, Ikematsu S, Enjyoji A, Yamanaka S, Kanematsu T (1994) Early lesions and modes of the spread of intrahepatic bile duct carcinoma — comparative study in hamster and man (in Japanese). Tan to Sui (J Bil Tract Pancr) 15:1011–1018

    Google Scholar 

  14. Fukahori T, Tomioka T, Inoue K, Tajima Y, Tsunoda T, Kanematsu T (1993) Establishment of a transplantable carcinoma arising from the intrahepatic bile duct in Syrian golden hamsters. Virchows Arch A Pathol Anat 422:233–238

    Google Scholar 

  15. Terada T, Nakanuma Y (1990) Pathological observation of intrahepatic peribiliary glands in 1000 consecutive autopsy livers. Hepatology 12:92–97

    Google Scholar 

  16. Motoo Y, Sawabu N, Minamoto T, Kawasaki H, Ohta H, Okai T, Fujimoto T, Mai M, Matsui O, Nakanishi I, Nakanuma Y. Rapidly growing mucinous cholangiocarcinoma. Internal Med 32:116–121

  17. Kikuchi S, Yago R, Watanabe K, Suzuki S (1973) A case of mucin-producing cystadenocarcinoma with obstructive jaundice (in Japanese). Geka (Surgery) 37:1193–1198

    Google Scholar 

  18. Kage M, Koga M, Hidaka H, Arakawa M, Kuwaki T, Inoue S, Kunisaki T, Kinoshita H, Nakayama K, Nakashima F, Shimokawa Y (1980) Two cases of mucin-producing intrahepatic cholangiocarcinoma with obstructive jaundice (in Japanese with English abstract). Acta Hepatologica Jpn 21:1068–1075

    Google Scholar 

  19. Ohta T, Konishi K, Higashino Y, Asano E, Izumi R, Nagakawa T, Kinami Y, Miyazaki I, Okada Y (1983) A case of mucinous biliary obstruction associated with multiple cholangiocarcinoma (in Japanese). Tan to Sui (J Bil Tract Pancr) 4:687–692

    Google Scholar 

  20. Hasegawa H, Nimura Y, Hayakawa N, Kamiya J, Maeda S, Iyomasa Y (1983) A case report of biliary cystadenocarcinoma diagnosed preoperatively by percutaneous transhepatic cholangioscopy (in Japanese with English abstract). Jpn Gastroenterol Surg Soc 16:1380–1383

    Google Scholar 

  21. Isogai M, Nimura Y, Hayakawa N, Hasegawa H, Asai M, Kamiya J, Maeda S, Okamoto K, Yamase H, Kishimoto H, Shionoya S, Kato S, Hayakawa M (1986) A case of mucus-producing cholangiocarcinoma with superficial spread (in Japanese with English abstract). J Jpn Gastroenterol Surg Soc 19:710–713

    Google Scholar 

  22. Chang JH, Togi F, Isiguro H, Tomatsu S, Oi I, Kozu T, Takeuchi T, Obara Y, Suzuki M, Ohashi M, Yosikawa T, Hanyu F (1987) Retention of mucinous material at the dilated orifice of papilla of Vater (in Japanese with English abstract). Gastroenterol Endosc 29:1506–1512

    Google Scholar 

  23. Matsui T, Fukai Y, Hotta A, Yoshikawa T, Kikukawa M, Shiratori T (1987) A case of mucus-producing cholangiocarcinoma with obstructive jaundice (in Japanese with English abstract). J Jpn Clin Surg Soc 48:557–561

    Google Scholar 

  24. Miyagawa S, Yamakawa M, Horiguchi Y, Miura K, Kawase K, Takayanagi K, Nakamura Y, Ohtani S, Miyata M, Shinoda S, Inagaki M, Ukai Y, Hadatsuki S, Ogura Y, Kuwabara T (1987) A case of early mucus-producing cholangiocarcinoma associated with intrahepatic gallstones (in Japanese with English abstract). J Jpn Biliary Assoc 1:209–216

    Google Scholar 

  25. Yamase H, Nimura Y, Hayakawa N, Hasegawa H, Maeda S, Kamiya J, Miyazaki Y, Okamoto K, Kishimoto H, Shionoya S (1987) A case of mucus-producing cholangiocarcinoma presenting as jaundice due to mucus obstruction (in Japanese with English abstract). J Jpn Gastroenterol Surg Soc 20:879–882

    Google Scholar 

  26. Akagi Y, Kiso T, Ohbayashi M, Matsui Y, Hino F, Kuroda Y, Ogawa Y, Itoh T (1988) A case of superficially spreading intrahepatic cholangiocarcinoma with left intrahepatic duct mucinous dilatation (in Japanese). Hiroshima Igaku 41:1513–1516

    Google Scholar 

  27. Iwase M, Nimura Y, Hayakawa N, Hasegawa H, Kamiya J, Shionoya S (1988) A case of biliary cystadenocarcinoma originating in the right caudal lobe, diagnosed by percutaneous transhepatic cholangioscopy before operation (in Japanese with English abstract). J Jpn Gastroenterol Surg Soc 21:905–908

    Google Scholar 

  28. Miyagawa S, Yamakawa M, Horiguchi Y, Nakamura S, Kimotsuki S, Horiguchi A, Kitano T, Imai H, Miura K (1988) A case of early intrahepatic bile duct carcinoma with mucus production (in Japanese). Tan to Sui (J Bil Tract Pancr) 9:1445–1453

    Google Scholar 

  29. Kurooka K, Yoshinobu H, Funai S, Ohnishi H, Sugimoto K, Kou K, Maruyama J, Nakai T, Shindo K, Yasutomi M, Shindo K, Yoshida A (1989) A case of mucus-producing cholangiocarcinoma diagnosed preoperatively (in Japanese). Tan to Sui (J Bil Tract Pancr) 10:1735–1740

    Google Scholar 

  30. Yamagiwa Y, Kurata M, Suzaki M (1991) A case of intrahepatic bile duct cancer obstructing the biliary tree by secreted mucus (in Japanese). Chiryo 73:195–198

    Google Scholar 

  31. Murayama M, Hatsuse K, Komiyama A, Tamakuma S, Terahata S (1991) A case of mucin-producing cholangiocarcinoma with cystic dilatation of the intrahepatic bile duct (in Japanese with English abstract). J Jpn Gastroenterol Surg Soc 24:2051–2055

    Google Scholar 

  32. Akiyama M, Mizushima Y, Karasawa G, Denno R (1992) Report of a resected case of cholangiocellular carcinoma originating in the caudate lobe (in Japanese with English abstract). J Jpn Gastroenterol Surg Soc 25:2009–2013

    Google Scholar 

  33. Hirano K, Konuma Y, Kikuchi H, Hatada Y, Tanaka M, Iwane K, Sudo T, Yoshida Y, Endo M, Sasaki M, Kudo K (1993) A case of mucin-producing bile duct carcinoma resected curatively after 2 years' follow-up (in Japanese). Tan to Sui (J Bil Tract Pancr) 14:1499–1506

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Second Department of Surgery, Kumamoto University Medical School, 1-1-1 Honjo, 860, Kumamoto, Japan

    Masahiko Hirota

  2. Departments of Surgery, Arao City Hospital, 2600 Arao, 864, Arao Kumamoto, Japan

    Masahiko Hirota, Hisami Ohshima & Katsumi Yamasaki

  3. Departments of Medicine, Arao City Hospital, 2600 Arao, 864, Arao Kumamoto, Japan

    Takashi Matsuo

  4. Second Department of Surgery, Nagasaki University Medical School, 1-7-1 Sakamoto, 852, Nagasaki, Japan

    Tsutomu Tomioka

  5. Department of Pathology, Ohshima County Municipal Hospital, 3411 Koyado, Naze, 894, Kagoshima, Japan

    Eio Atari

Authors
  1. Masahiko Hirota
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tsutomu Tomioka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hisami Ohshima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Katsumi Yamasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takashi Matsuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Eio Atari
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Hirota, M., Tomioka, T., Ohshima, H. et al. Mucin-producing bile duct carcinoma originating at the hepatic hilus. J Hep Bil Pancr Surg 4, 135–140 (1997). https://doi.org/10.1007/BF01211356

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01211356

Key words

Search

Navigation